ArticleBioMed research international2017
White Matter Integrity in Genetic High-Risk Individuals and First-Episode Schizophrenia Patients: Similarities and Disassociations.
Article in BioMed research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Structural connectivity associated with familial risk for mental illness: A meta-analysis of diffusion tensor imaging studies in relatives of patients with severe mental disorders.Human brain mapping · 2022Pooled it
- White Matter Integrity of the Three Subdivisions of the Superior Longitudinal Fasciculi in First-Episode Psychosis Patients.Psychiatry investigation · 2025Article
- Longitudinal Associations Between Self-reported Schizotypy Dimensions and White Matter Integrity Development During Adolescence.Schizophrenia bulletin · 2025Article
- Microstructural changes along the cingulum in young adolescents with psychotic experiences: An along-tract analysis.The European journal of neuroscience · 2022Article
- Tract-specific white matter microstructural alterations in subjects with schizophrenia and unaffected first-degree relatives.Brain imaging and behavior · 2022Article
- Relationship of Corpus Callosum Integrity with Working Memory, Planning, and Speed of Processing in Patients with First-Episode and Chronic Schizophrenia.Journal of clinical medicine · 2021Article
- Executive Dysfunctions in Schizophrenia: A Critical Review of Traditional, Ecological, and Virtual Reality Assessments.Journal of clinical medicine · 2021Review
- Multimodal MRI assessment for first episode psychosis: A major change in the thalamus and an efficient stratification of a subgroup.Human brain mapping · 2021Article
- White Matter Microstructure across the Psychosis Spectrum.Trends in neurosciences · 2020Review
- Disruptions in White Matter Maturation and Mediation of Cognitive Development in Youths on the Psychosis Spectrum.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- The development of brain white matter microstructure.NeuroImage · 2018Review
- Is Schizophrenia a Disorder of Consciousness? Experimental and Phenomenological Support for Anomalous Unconscious Processing.Frontiers in psychology · 2017Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
White matter (WM) neuroimaging studies have shown varied findings at different stages of schizophrenia (SZ). Understanding these variations may elucidate distinct markers of genetic vulnerability and conversion to psychosis. To examine the similarities and differences in WM connectivity between those at-risk for and in early stages of SZ, a cross-sectional diffusion tensor imaging study of 48 individuals diagnosed with first-episode SZ (FE-SZ), 37 nonpsychotic individuals at a high genetic risk of SZ (GHR-SZ), and 67 healthy controls (HC) was conducted. Decreased fractional anisotropy (FA) in the corpus callosum (CC), anterior cingulum (AC), and uncinate fasciculus (UF) was observed in both the GHR-SZ and FE-SZ groups, while decreased FAs in the superior longitudinal fasciculus (SLF) and the fornix were only seen in the FE-SZ participants. Additionally, both GHR-SZ and FE-SZ showed worse executive performance than HC. The left SLF III FA was significantly positively correlated with hallucinations, and right SLF II was positively correlated with thought disorder. The presence of shared WM deficits in both FE-SZ and GHR-SZ individuals may reflect the genetic liability to SZ, while the disparate FA changes in the FE-SZ group may represent symptom-generating circuitry that mediates perceptual and cognitive disturbances of SZ and ultimately culminates in the onset of psychotic episodes.
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