ArticleCMAJ open
Time trends in organ donation after neurologic determination of death: a cohort study.
Article in CMAJ open. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Organ donation and brain preservation after assisted dying: case report and considerations for a potential pathway.BMC medical ethics · 2026Article
- Surgical Strategies for Renal Transplantation: A Pictorial Essay.Journal of clinical medicine · 2024Review
- Program of Uncontrolled Donation After Circulatory Death as Potential Solution to the Shortage of Organs: A Canadian Single-Center Retrospective Cohort Study.Open access emergency medicine : OAEM · 2022Article
- Hemodynamic management in brain dead donors.World journal of transplantation · 2021Review
- Donation after circulatory determination of death in western Canada: a multicentre study of donor characteristics and critical care practices.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2020Article
- Improved long-term outcomes after heart transplantation utilizing donors with a traumatic mode of brain death.Journal of cardiothoracic surgery · 2019Observational
- Epidemiological changes in potential heart donors after brain death: a retrospective 15 year cohort study.Internal and emergency medicine · 2019Article
- Trends in deceased organ donation in Canada.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2017Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe cause of brain injury may influence the number of organs that can be procured and transplanted with donation following neurologic determination of death. We investigated whether the distribution of causes responsible for neurologic death has changed over time and, if so, whether this has had an impact on organ quality, transplantation rates and recipient outcomes.
methodsWe performed a cohort study involving consecutive brain-dead organ donors in southern Alberta between 2003 and 2014. For each donor, we determined last available measures of organ injury and number of organs transplanted, and compared these variables for various causes of neurologic death. We compared trends to national Canadian data for 2000-2013 (2000-2011 for Quebec).
resultsThere were 226 brain-dead organ donors over the study period, of whom 100 (44.2%) had anoxic brain injury, 63 (27.9%) had stroke, and 51 (22.6%) had traumatic brain injury. The relative proportion of donors with traumatic brain injury decreased over time (> 30% in 2003-2005 v. 6%-23% in 2012-2014) (
interpretationAnoxic brain injury has become a leading cause of organ donation after neurologic determination of death in Canada. Organs from donors with anoxic brain injury have a greater degree of injury, and fewer are transplanted. These findings have implications for availability of organs for transplantation in patients with end-stage organ failure.
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Registered trials
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