Evidence map›Paper›PMID 28400986›Full record

ArticleAging and disease2017

Combining Injectable Plasma Scaffold with Mesenchymal Stem/Stromal Cells for Repairing Infarct Cavity after Ischemic Stroke.

Hongxia Zhang, Fen Sun, Jixian Wang, Luokun Xie, Chenqi Yang, Mengxiong Pan, Bei Shao, Guo-Yuan Yang, Shao-Hua Yang, Qichuan ZhuGe and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging and disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hongxia Zhang1Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China; 2Institute for Healthy Aging, University of North Texas Health Science Center at Fort Worth, TX 76107, USA.
Fen Sun2Institute for Healthy Aging, University of North Texas Health Science Center at Fort Worth, TX 76107, USA.
Jixian Wang2Institute for Healthy Aging, University of North Texas Health Science Center at Fort Worth, TX 76107, USA; 3Department of Rehabilitation, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Luokun Xie2Institute for Healthy Aging, University of North Texas Health Science Center at Fort Worth, TX 76107, USA.
Chenqi Yang2Institute for Healthy Aging, University of North Texas Health Science Center at Fort Worth, TX 76107, USA.
Mengxiong Pan1Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China; 2Institute for Healthy Aging, University of North Texas Health Science Center at Fort Worth, TX 76107, USA.
Bei Shao1Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
Guo-Yuan Yang4Med-x Research Institute, Shanghai Jiao Tong University, Shanghai, China.
Shao-Hua Yang2Institute for Healthy Aging, University of North Texas Health Science Center at Fort Worth, TX 76107, USA.
Qichuan ZhuGe1Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
Kunlin Jin1Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China; 2Institute for Healthy Aging, University of North Texas Health Science Center at Fort Worth, TX 76107, USA.

Funding

Aging and NeurogenesisR01AG021980 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI JIN, KUNLIN · 2003 to 2014
$3.9M
Neuroglobin: cell metabolism and neuroprotectionR01NS088596 · NINDS · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI YANG, SHAOHUA · 2014 to 2018
$1.6M
Functional contribution of neural stem cells in strokeR01NS057186 · NINDS · BUCK INSTITUTE FOR RESEARCH ON AGING · PI JIN, KUNLIN · 2009 to 2010
$970k
Establishment of inducible astrocyte specific p38 MAPK knockout mouse lineR21NS087209 · NINDS · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI YANG, SHAOHUA · 2014 to 2015
$402k
Impacts of the systemic milieu on stroke outcomeR21NS094859 · NINDS · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI JIN, KUNLIN · 2016 to 2017
$402k
NIA NIH HHS R01 AG021980NINDS NIH HHS R01 NS057186NINDS NIH HHS R01 NS088596NINDS NIH HHS R21 NS087209NINDS NIH HHS R21 NS094859
6 · The paper itself

Abstract

Stroke survivors are typically left with structural brain damage and associated functional impairment in the chronic phase of injury, for which few therapeutic options exist. We reported previously that transplantation of human embryonic stem cell (hESC)-derived neural stem cells together with Matrigel scaffolding into the brains of rats after focal ischemia reduced infarct volume and improved neurobehavioral performance. Matrigel is a gelatinous protein mixture extracted from mouse sarcoma cells, thus would not be approved for use as a scaffold clinically. In this study, we generated a gel-like scaffold from plasma that was controlled by changing the concentration of CaCl

Indexed as

agingaging-related diseasesdiagnosisfrailtyregulationsenescence

Identifiers

PMID28400986
PMCPMC5362179

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.