Evidence map›Paper›PMID 28400812›Full record

ArticleNeural regeneration research2017

Edaravone protects against oxygen-glucose-serum deprivation/restoration-induced apoptosis in spinal cord astrocytes by inhibiting integrated stress response.

Bin Dai, Ting Yan, Yi-Xing Shen, You-Jia Xu, Hai-Bin Shen, Dong Chen, Jin-Rong Wang, Shuang-Hua He, Qi-Rong Dong, Ai-Liang Zhang

Open access · goldAbstract read
In one paragraph

Article in Neural regeneration research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Neuroprotective Effect of Polyphenol Extracts fromMolecules (Basel, Switzerland) · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Bin DaiDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China; Department of Orthopedics, Binhai County People's Hospital, Binhai, Jiangsu Province, China.
Ting YanSafety Assessment and Research Center for Drug, Pesticide and Veterinary Drug of Jiangsu Province, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Yi-Xing ShenDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
You-Jia XuDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
Hai-Bin ShenDepartment of Orthopedics, Binhai County People's Hospital, Binhai, Jiangsu Province, China.
Dong ChenDepartment of Orthopedics, Binhai County People's Hospital, Binhai, Jiangsu Province, China.
Jin-Rong WangDepartment of Orthopedics, Binhai County People's Hospital, Binhai, Jiangsu Province, China.
Shuang-Hua HeDepartment of Orthopedics, Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu Province, China.
Qi-Rong DongDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.ORCID 0000-0003-2916-5792
Ai-Liang ZhangDepartment of Orthopedics, Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu Province, China.
Soochow University · CNBinzhou People's Hospital · CNSecond Affiliated Hospital of Soochow University · CNNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We previously found that oxygen-glucose-serum deprivation/restoration (OGSD/R) induces apoptosis of spinal cord astrocytes, possibly

Indexed as

activating transcription factor 4apoptosisastrocytescaspase-12caspase-3CCAAT/enhancer binding protein homologous proteinedaravoneeIF2αintegrated stress responsenerve regenerationneural regenerationPERKreactive oxygen species

Identifiers

PMID28400812
PMCPMC5361514
OpenAlexW2581360858

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.