ArticleFrontiers in behavioral neuroscience2017
Sex Differences in the Physiological and Behavioral Effects of Chronic Oral Methylphenidate Treatment in Rats.
Article in Frontiers in behavioral neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Context-dependent attention and memory outcomes resulting from combined prenatal THC and nicotine exposure following chronic stress.Pharmacology, biochemistry, and behavior · 2026Article
- Chronic Co-administration of Methylphenidate and Fluoxetine Reduces Striatal NMDA Receptor Binding in Adolescent Rats.Neurochemical research · 2026Article
- From early-life fluoxetine exposure to lifelong, sex-specific behavioral changes: decoding the dynamics of sensitive periods.Molecular psychiatry · 2026Article
- Sex differences in the response to treatment of attention deficit hyperactivity disorder.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Chronic Combined Oral Methylphenidate and Fluoxetine Increases Inflammation in Somatosensory and Mesolimbic Brain Regions.Neurochemical research · 2025Article
- Lack of Sex Differences in Psychostimulant-Induced Locomotor Activity When Comparing Rats From the Same Behavioral Groups.Biological psychiatry global open science · 2025Article
- Vaporized nicotine in utero results in reduced birthweight, increased locomotion, and decreased voluntary exercise, dependent on sex and diet in offspring.Psychopharmacology · 2024Article
- Chronic Methylphenidate Effects on Brain Gene Expression: An Exploratory Review.Psychology research and behavior management · 2024Review
- Vaporized Delta-9-tetrahydrocannabinol Inhalation in Female Sprague Dawley Rats: A Pharmacokinetic and Behavioral Assessment.Current pharmaceutical design · 2023Article
- Object recognition tasks in rats: Does sex matter?Frontiers in behavioral neuroscience · 2022Review
- Fluoxetine Potentiates Oral Methylphenidate-Induced Gene Regulation in the Rat Striatum.Molecular neurobiology · 2021Article
- Brief and extended abstinence from chronic oral methylphenidate treatment produces reversible behavioral and physiological effects.Developmental psychobiology · 2020Article
- Weekday-only chronic oral methylphenidate self-administration in male rats: Reversibility of the behavioral and physiological effects.Behavioural brain research · 2019Article
- Chronic oral methylphenidate treatment increases microglial activation in rats.Journal of neural transmission (Vienna, Austria : 1996) · 2018Article
- Recovery from behavior and developmental effects of chronic oral methylphenidate following an abstinence period.Pharmacology, biochemistry, and behavior · 2018Article
- Adolescent food restriction in rats alters prefrontal cortex microglia in an experience-dependent manner.Stress (Amsterdam, Netherlands) · 2018Article
- Methylphenidate regulation of osteoclasts in a dose- and sex-dependent manner adversely affects skeletal mechanical integrity.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
Methylphenidate (MP) is a psychostimulant prescribed for Attention Deficit Hyperactivity Disorder. Previously, we developed a dual bottle 8-h-limited-access-drinking-paradigm for oral MP treatment of rats that mimics the pharmacokinetic profile of treated patients. This study assessed sex differences in response to this treatment. Male and female Sprague Dawley rats were assigned to one of three treatment groups at 4 weeks of age (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.