Evidence map›Paper›PMID 28400678›Full record

ArticleMediators of inflammation2017

Key Role of STAT4 Deficiency in the Hematopoietic Compartment in Insulin Resistance and Adipose Tissue Inflammation.

Anca D Dobrian, Kaiwen Ma, Lindsey M Glenn, Margaret A Hatcher, Bronson A Haynes, Eric J Lehrer, Mark H Kaplan, Jerry L Nadler

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. STAT4: an immunoregulator contributing to diverse human diseases.International journal of biological sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Anca D DobrianDepartment of Physiological Sciences, Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, VA, USA.ORCID 0000-0003-3322-4214
Kaiwen MaDepartment of Internal Medicine, Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, VA, USA.
Lindsey M GlennDepartment of Internal Medicine, Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, VA, USA.
Margaret A HatcherDepartment of Physiological Sciences, Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, VA, USA.
Bronson A HaynesDepartment of Physiological Sciences, Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, VA, USA.
Eric J LehrerDepartment of Physiological Sciences, Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, VA, USA.
Mark H KaplanDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
Jerry L NadlerDepartment of Internal Medicine, Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, VA, USA.ORCID 0000-0002-4200-6991
Eastern Virginia Medical School · USIndiana University School of Medicine

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Visceral adipose tissue (AT) inflammation is linked to the complications of obesity, including insulin resistance (IR) and type 2 diabetes. Recent data from our lab showed that germline deficiency in STAT4 reduces inflammation and improves IR in obese mice. The objective of this study was to determine the contribution of selective STAT4 deficiency in subsets of hematopoietic cells to IR and AT inflammation. To determine the contribution of hematopoietic lineage, we sublethally irradiated

Indexed as

AdipocytesAdipose TissueAnimalsBlotting, WesternFlow CytometryHematopoiesisInflammationInsulinInsulin ResistanceMaleMiceMice, Inbred C57BLMice, KnockoutReal-Time Polymerase Chain ReactionSTAT4 Transcription FactorInsulinStat4 protein, mouseSTAT4 Transcription Factor

Identifiers

PMID28400678
PMCPMC5376449
OpenAlexW2595835233

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.