Trial reportScientific reports2017
Maternal plasma miRNAs as biomarkers during mid-pregnancy to predict later spontaneous preterm birth: a pilot study.
Trial report in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 61 citations in OpenAlex.
- MicroRNA-548 regulates high mobility group box 1 expression in patients with preterm birth and chorioamnionitis.Scientific reports · 2019Trial
- The single-cell immune profile throughout gestation and its potential value for identifying women at risk for spontaneous preterm birth.European journal of obstetrics & gynecology and reproductive biology: X · 2025Review
- Circulating microRNAs in Body Fluid: "Fingerprint" RNA Snippets Deeply Impact Reproductive Biology.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Extracellular vesicles and preterm infant diseases.Frontiers in pediatrics · 2025Review
- Maternal Plasma miRNAs as Early Biomarkers of Moderate-to-Late-Preterm Birth.International journal of molecular sciences · 2024Article
- Value of Non-Coding RNA Expression in Biofluids to Identify Patients at Low Risk of Pathologies Associated with Pregnancy.Diagnostics (Basel, Switzerland) · 2024Review
- Recent Advances and Challenges in the Early Diagnosis and Treatment of Preterm Labor.Bioengineering (Basel, Switzerland) · 2024Review
- Maternal-Infant Factors in Relation to Extracellular Vesicle and Particle miRNA in Prenatal Plasma and in Postpartum Human Milk.International journal of molecular sciences · 2024Article
- EV-miRNA associated with environmental air pollution exposures in the MADRES cohort.Environmental epigenetics · 2024Article
- Assessment of NanoString technology as a tool for profiling circulating miRNA in maternal blood during pregnancy.Extracellular vesicles and circulating nucleic acids · 2024Article
- Emerging role of toll-like receptors signaling and its regulators in preterm birth: a narrative review.Archives of gynecology and obstetrics · 2023Review
- Placental microRNA methylome signatures may serve as biomarkers and therapeutic targets for prenatally opioid-exposed infants with neonatal opioid withdrawal syndrome.Frontiers in genetics · 2023Article
- The role of miRNA-210 in pre-eclampsia development.Annals of medicine · 2022Review
- First Trimester Maternal Plasma Aberrant miRNA Expression Associated with Spontaneous Preterm Birth.International journal of molecular sciences · 2022Article
- Article
- Exosomes and exosomal non-coding RNAs throughout human gestation (Review).Experimental and therapeutic medicine · 2022Review
- The implications of exosomes in pregnancy: emerging as new diagnostic markers and therapeutics targets.Cell communication and signaling : CCS · 2022Review
- Systematic review of preterm birth multi-omic biomarker studies.Expert reviews in molecular medicine · 2022Review
- Extracellular vesicle microRNA in early versus late pregnancy with birth outcomes in the MADRES study.Epigenetics · 2022Article
- Genome and transcriptome profiling of spontaneous preterm birth phenotypes.Scientific reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
More than 10% of babies are born too early resulting in over 15 million preterm births and more than one million new-born deaths globally. Although women with a previous spontaneous preterm birth (SPTB) are considered at high risk for recurrence, the majority occur in women without prior history. Prediction of SPTB risk allows for improved care and potential for targeting novel and existing therapeutics to prevent SPTB, which may result in improved outcomes for infant and mother. In this pilot study, a miRNA array was used to analyse plasma from healthy women in their first pregnancy at 20 weeks of gestation who then went on to deliver either at term or experience SPTB at 28-32 weeks. We identified specific miRNA expression profiles that differentiated between those mothers who delivered at term or delivered following SPTB. miR302b, miR1253 and a clustering of miR548 miRNAs were underexpressed in SPTB cases compared to term controls. Conversely, miR223 was elevated in mothers that later experienced a SPTB. The circulating miRNAs identified in the present study may therefore be attractive candidates as non-invasive biomarkers for the early prediction of SPTB. Further larger studies are now warranted to investigate the potential clinical utility of these markers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.