ArticleEmerging microbes & infections2017
Pathogenicity and transmission of a swine influenza A(H6N6) virus.
Article in Emerging microbes & infections, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Transmission Pathways of Zoonotic Influenza Viruses and Influencing Factors: A Systematic Review of Recent Findings.Viruses · 2025Pooled it
- Global distribution, receptor binding, and cross-species transmission of H6 influenza viruses: risks and implications for humans.Journal of virology · 2023Review
- Influenza A (H6N6) viruses isolated from chickens replicate in mice and human lungs without prior adaptation.Journal of virus eradication · 2022Article
- Effect of SerialJournal of veterinary research · 2022Article
- Mouse adaptation of H6 avian influenza viruses and their molecular characteristics.Frontiers in microbiology · 2022Article
- Genetic characterization and evolution of H6N6 subtype avian influenza viruses.Frontiers in microbiology · 2022Article
- Deciphering transmission dynamics and spillover of avian influenza viruses from avian species to swine populations globally.Virus genes · 2021Article
- Triple reassortment increases compatibility among viral ribonucleoprotein genes of contemporary avian and human influenza A viruses.PLoS pathogens · 2021Article
- Metabolomic Profiles of Men and Women Ischemic Stroke Patients.Diagnostics (Basel, Switzerland) · 2021Article
- Characterization of Subtype H6 Avian Influenza A Viruses Isolated From Wild Birds in Poyang Lake, China.Frontiers in veterinary science · 2021Article
- Tissue Tropisms of Avian Influenza A Viruses Affect Their Spillovers from Wild Birds to Pigs.Journal of virology · 2020Article
- Review
- Continuing evolution of H6N2 influenza a virus in South African chickens and the implications for diagnosis and control.BMC veterinary research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 7 institutions in 2 countries.
Funding
Abstract
Subtype H6 influenza A viruses (IAVs) are commonly detected in wild birds and domestic poultry and can infect humans. In 2010, a H6N6 virus emerged in southern China, and since then, it has caused sporadic infections among swine. We show that this virus binds to α2,6-linked and α2,3-linked sialic acids. Mutations at residues 222 (alanine to valine) and 228 (glycine to serine) of the virus hemagglutinin (HA) affected its receptor-binding properties. Experiments showed that the virus has limited transmissibility between ferrets through direct contact or through inhalation of infectious aerosolized droplets. The internal genes of the influenza A(H1N1)pdm09 virus, which is prevalent in swine worldwide, increases the replication efficiency of H6N6 IAV in the lower respiratory tract of ferrets but not its transmissibility between ferrets. These findings suggest H6N6 swine IAV (SIV) currently poses a moderate risk to public health, but its evolution and spread should be closely monitored.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.