Evidence map›Paper›PMID 28400540›Full record

ArticleJournal of leukocyte biology2017

CD56

Chelsey J Judge, Lenche Kostadinova, Kenneth E Sherman, Adeel A Butt, Yngve Falck-Ytter, Nicholas T Funderburg, Alan L Landay, Michael M Lederman, Scott F Sieg, Johan K Sandberg and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of leukocyte biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. CD8Frontiers in immunology · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Targeting natural killer cells in solid tumors.Cellular & molecular immunology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 3 countries.

Chelsey J JudgeDepartment of Pathology, Cleveland VA Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
Lenche KostadinovaDepartment of Medicine, University Hospitals Case Medical Center and Center for AIDS Research (CFAR), Case Western Reserve University, Cleveland, Ohio, USA.
Kenneth E ShermanDepartment of Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio, USA.
Adeel A ButtWeill Cornell Medical College, New York, New York, USA.
Yngve Falck-YtterDepartment of Pathology, Cleveland VA Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
Nicholas T FunderburgSchool of Health and Rehabilitation, Division of Medical Laboratory Science, The Ohio State University, Columbus, Ohio, USA.
Alan L LandayRush University Medical Center, Chicago, Illinois, USA: and.
Michael M LedermanDepartment of Medicine, University Hospitals Case Medical Center and Center for AIDS Research (CFAR), Case Western Reserve University, Cleveland, Ohio, USA.
Scott F SiegDepartment of Medicine, University Hospitals Case Medical Center and Center for AIDS Research (CFAR), Case Western Reserve University, Cleveland, Ohio, USA.
Johan K SandbergCenter for Infection Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Donald D AnthonyDepartment of Pathology, Cleveland VA Medical Center, Case Western Reserve University, Cleveland, Ohio, USA; dda3@case.edu.
Case Western Reserve University · USUniversity Hospitals Case Medical Center · USCornell University · USKarolinska University Hospital · SERush University Medical Center · USThe Ohio State University · USUniversity of Cincinnati · US

Funding

Leadership and Operations Center (LOC), AIDS Clinical Trials Group (ACTG); LOC 1/UM1AI068636 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph J Eron, RAJESH T GANDHI · 2011 to 2026
$1073.1M
Statistical and Data Management Center (SDMC), AIDS Clinical Trials Group (ACTG)UM1AI068634 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Marlene Ann Cooper, Michael David Hughes · 2011 to 2026
$246.6M
AIDS Clinical Trials Group NetworkU01AI068636 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI KURITZKES, DANIEL R. · 2006 to 2010
$147.1M
Validation, CLIA and Qualification (VQC): Enhancing the RS ratio as a tool for AIDS Clinical Trial Group (ACTG) tuberculosis trialsUM1AI106701 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Grace M Aldrovandi · 2014 to 2026
$116.8M
Case Clinical Trials Unit: Administrative Supplement NOSI AI-20-031.UM1AI069501 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI George Yendewa · 2012 to 2026
$40.4M
University of Puerto Rico Clinical Trials UnitUM1AI069415 · NIAID · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI FEBO, IRMA LUZ, SANTANA-BAGUR, JORGE L. · 2012 to 2021
$15.2M
Role of IL28B and HIV in NK Control of HCVR21AI100809 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI ANTHONY, DONALD D · 2012 to 2013
$420k
Role of ENPP2, immune activation and age on neoantigen response during HCVI01CX001104 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI ANTHONY, DONALD D · 2015 to 2018
–
Role of NK cells in control of HCV infection associated hepatocellular carcinomaI01BX001894 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI Donald D Anthony · 2013 to 2026
–
BLRD VA I01 BX001894CSRD VA I01 CX001104NIAID NIH HHS R21 AI100809NIAID NIH HHS U01 AI068636NIAID NIH HHS UM1 AI068634NIAID NIH HHS UM1 AI069415NIAID NIH HHS UM1 AI069501NIAID NIH HHS UM1 AI106701
6 · The paper itself

Abstract

Several lines of evidence support the concept that NK cells play an important role in control of hepatitis C virus (HCV) infection via cytokine secretion and cytotoxicity. IL-7 is a homeostatic cytokine with a role in T cell development, activation, proliferation, and cytokine secretion. The IL-7Rα chain [cluster of differentiation (CD)127] is expressed on NK cells, with greatest abundance on the CD56

Indexed as

AdultAgedAged, 80 and overAntigens, CDCD56 AntigenFemaleGene Expression RegulationHepatitis C, ChronicHIV-1HIV InfectionsHumansInterleukin-7Interleukin-7 Receptor alpha SubunitKiller Cells, NaturalMaleMiddle AgedAntigens, CDCD56 AntigenIL7 protein, humanIL7R protein, humanInterleukin-7Interleukin-7 Receptor alpha SubunitNCAM1 protein, humanSTAT5 Transcription Factorcellular immunityhost defenseIFN-γinnate immunityviral immunity

Identifiers

PMID28400540
PMCPMC5470838
OpenAlexW2606087156

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.