Evidence map›Paper›PMID 28400426›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2017

A Gene Signature for Selecting Benefit from Hypoxia Modification of Radiotherapy for High-Risk Bladder Cancer Patients.

Lingjian Yang, Janet Taylor, Amanda Eustace, Joely J Irlam, Helen Denley, Peter J Hoskin, Jan Alsner, Francesca M Buffa, Adrian L Harris, Ananya Choudhury and 1 more

Registry-linked trialOpen access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06787053 (Selecting Hypoxic Tumours for Treatment Modification), which is not on this map. Cited by 66 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06787053 recruitingnot on this mapstarted 2024, after this paper: background citation

Selecting Hypoxic Tumours for Treatment Modification

TypeobservationalSponsorUniversity of ManchesterRan2024 to 2028Enrolled30ConditionsBladder (Urothelial, Transitional Cell) Cancer, Prostate Cancer
3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 1 synthesis or guideline pooled it, 128 citations in OpenAlex.

  1. Pooled it
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  7. Multi-omics exploration of hypoxia in gastric cancer.World journal of surgical oncology · 2026
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Lingjian YangTranslational Radiobiology Group, Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital, Manchester, United Kingdom.
Janet TaylorTranslational Radiobiology Group, Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital, Manchester, United Kingdom.
Amanda EustaceTranslational Radiobiology Group, Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital, Manchester, United Kingdom.
Joely J IrlamTranslational Radiobiology Group, Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital, Manchester, United Kingdom.
Helen DenleyDepartment of Cellular Pathology, Manchester Royal Infirmary, Manchester, United Kingdom.
Peter J HoskinCancer Centre, Mount Vernon Hospital, Rickmansworth Road, Northwood, Middlesex, United Kingdom.
Jan AlsnerDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Francesca M BuffaWeatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
Adrian L HarrisWeatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
Ananya ChoudhuryTranslational Radiobiology Group, Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital, Manchester, United Kingdom.
Catharine M L WestTranslational Radiobiology Group, Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital, Manchester, United Kingdom. catharine.west@manchester.ac.uk.
MRC Weatherall Institute of Molecular Medicine · GB

Funding

Cancer Research UK 11359Cancer Research UK 16466Cancer Research UK 18974Cancer Research UK 23969Medical Research Council G0300648Medical Research Council G0801525
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgedCarbon DioxideClinical Trials, Phase III as TopicFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansHypoxiaKaplan-Meier EstimateMaleMiddle AgedNiacinamideOxygenPrognosisRandomized Controlled Trials as TopicRisk FactorscarbogenCarbon DioxideNiacinamideOxygen

Identifiers

PMID28400426
OpenAlexW2605993275

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.