ArticleThe British journal of ophthalmology2017
Retinal microvascular network geometry and cognitive abilities in community-dwelling older people: The Lothian Birth Cohort 1936 study.
Article in The British journal of ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Predicting stroke risk using retinal imaging with artificial intelligence: a scoping review of current evidence.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- Effect of using different fundus cameras and image resolutions on automatic measurements of retinal vascular parameters.Scientific reports · 2026Article
- Comparison of the additive value of blood-based and retinal biomarkers to clinical features in predicting cognitive decline.Communications medicine · 2025Article
- A deep-learning retinal aging biomarker for cognitive decline and incident dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The role of retinal vessel geometry as an indicator of systemic arterial stiffness assessed by cardio-ankle vascular index.Frontiers in cardiovascular medicine · 2023Article
- Changes in retinal vascular bifurcation in eyes with myopia.BMC ophthalmology · 2022Article
- Concordance between SIVA, IVAN, and VAMPIRE Software Tools for Semi-Automated Analysis of Retinal Vessel Caliber.Diagnostics (Basel, Switzerland) · 2022Article
- Retinal microvasculature and imaging markers of brain frailty in normal aging adults.Frontiers in aging neuroscience · 2022Article
- A Study of the Association Between Retinal Vessel Geometry and Optical Coherence Tomography Angiography Metrics in Diabetic Retinopathy.Investigative ophthalmology & visual science · 2021Article
- Retinal arteriolar tortuosity and fractal dimension are associated with long-term cardiovascular outcomes in people with type 2 diabetes.Diabetologia · 2021Article
- Denser Retinal Microvascular Network Is Inversely Associated With Behavioral Outcomes and Sustained Attention in Children.Frontiers in neurology · 2021Article
- Predicting High Coronary Artery Calcium Score From Retinal Fundus Images With Deep Learning Algorithms.Translational vision science & technology · 2020Article
- Retinal microvascular features and cognitive change in the Lothian-Birth Cohort 1936.Alzheimer's & dementia (Amsterdam, Netherlands) · 2019Article
- Towards Accurate Segmentation of Retinal Vessels and the Optic Disc in Fundoscopic Images with Generative Adversarial Networks.Journal of digital imaging · 2019Article
- Cohort Profile Update: The Lothian Birth Cohorts of 1921 and 1936.International journal of epidemiology · 2018Article
- Reproducibility of Retinal Microvascular Traits Decoded by the Singapore I Vessel Assessment Software Across the Human Age Range.American journal of hypertension · 2018Article
- Towards Standardization of Quantitative Retinal Vascular Parameters: Comparison of SIVA and VAMPIRE Measurements in the Lothian Birth Cohort 1936.Translational vision science & technology · 2018Article
- Retinal microvasculature and incident dementia over 10 years: The Three-City-Alienor cohort.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
aimTo examine the relationship between retinal vascular morphology and cognitive abilities in a narrow-age cohort of community-dwelling older people.
methodsDigital retinal images taken at age ∼73 years from 683 participants of the Lothian Birth Cohort 1936 (LBC1936) were analysed with Singapore I Vessel Assessment (SIVA) software. Multiple regression models were applied to determine cross-sectional associations between retinal vascular parameters and general cognitive ability (
resultsAfter adjustment for cognitive ability at age 11 years and cardiovascular risk factors, venular length-to-diameter ratio was nominally significantly associated with processing speed (β=-0.116, p=0.01) and
conclusionsRetinal parameters contributed <1% of the variance in the majority of associations observed. Whereas retinal analysis may have potential for early detection of some types of age-related cognitive decline and dementia, our results present little evidence that retinal vascular features are associated with non-pathological cognitive ageing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.