ArticleJournal of the American Heart Association2017
In Utero Particulate Matter Exposure Produces Heart Failure, Electrical Remodeling, and Epigenetic Changes at Adulthood.
Open access · goldAbstract read
In one paragraph
Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Ambient air pollution and cardiovascular diseases: An umbrella review of systematic reviews and meta-analyses.Journal of internal medicine · 2022Pooled it
- Cardiopulmonary and Immune Effects of Environmental Particulate Exposures.Physiology (Bethesda, Md.) · 2026Review
- The environmental exposome in heart failure risk and progression.Nature reviews. Cardiology · 2026Review
- A comprehensive review on the role of PM2.5 in modulating transplant immunity and graft survival.Particle and fibre toxicology · 2026Review
- 12,13-diHOME protects against the age-related decline in cardiovascular function via attenuation of CaMKII.Nature communications · 2025Article
- Environmental pollutants and atherosclerosis: Epigenetic mechanisms linking genetic risk and disease.Atherosclerosis · 2025Review
- Ambient Air Pollution and Congenital Heart Disease: Updated Evidence and Future Challenges.Antioxidants (Basel, Switzerland) · 2025Review
- Prenatal black carbon exposure and DNA methylation in umbilical cord blood.International journal of hygiene and environmental health · 2025Article
- Guidelines for in vivo models of developmental programming of cardiovascular disease risk.American journal of physiology. Heart and circulatory physiology · 2024Review
- Review
- Review
- The macrophage senescence hypothesis: the role of poor heat shock response in pulmonary inflammation and endothelial dysfunction following chronic exposure to air pollution.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022Review
- Sex-Dependent Responses to Maternal Exposure to PMAntioxidants (Basel, Switzerland) · 2022Article
- Association Between Long-term Ambient PMAmerican journal of kidney diseases : the official journal of the National Kidney Foundation · 2022Article
- Adverse effects of air pollution-derived fine particulate matter on cardiovascular homeostasis and disease.Trends in cardiovascular medicine · 2022Review
- Molecular signature of cardiac remodeling associated with Polymerase Gamma mutation.Life sciences · 2022Article
- Modeling complex effects of exposure to particulate matter and extreme heat during pregnancy on congenital heart defects: A U.S. population-based case-control study in the National Birth Defects Prevention Study.The Science of the total environment · 2022Article
- Developmental toxicant exposures and sex-specific effects on epigenetic programming and cardiovascular health across generations.Environmental epigenetics · 2022Review
- HSP70 as a biomarker of the thin threshold between benefit and injury due to physical exercise when exposed to air pollution.Cell stress & chaperones · 2021Review
- Particulate matter 2.5 triggers airway inflammation and bronchial hyperresponsiveness in mice by activating the SIRT2-p65 pathway.Frontiers of medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Vineeta TanwarDorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH.
Matthew W GorrDorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH.
Markus VeltenDepartment of Anesthesiology and Intensive Care Medicine, Rheinische Friedrich-Wilhelms-University, University Medical Center, Bonn, Germany.
Clayton M EichenseerDorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH.
Victor P LongDorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH.
Ingrid M BonillaDorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH.
Vikram ShettigarDepartment of Physiology and Cell Biology, The Ohio State University, Columbus, OH.
Mark T ZioloDepartment of Physiology and Cell Biology, The Ohio State University, Columbus, OH.
Jonathan P DavisDepartment of Physiology and Cell Biology, The Ohio State University, Columbus, OH.
Stephen H BaineCollege of Pharmacy, The Ohio State University, Columbus, OH.
Cynthia A CarnesDorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH.
Loren E WoldDorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH loren.wold@osumc.edu.
The Ohio State University · USLung Institute · US
Funding
Mechanisms of exposure-induced tissue functional and pathological changes in a mouse model of Alzheimer's DiseaseR01AG057046 · NIA · OHIO STATE UNIVERSITY · PI COMBS, COLIN K, DEL MONTE, FEDERICA · 2017 to 2021
$4.0MMuscle function and depression-like behavior in a mouse model of cancer fatigueR01NR012618 · NINR · OHIO STATE UNIVERSITY · PI REISER, PETER J, WOLD, LOREN EUGENE · 2012 to 2016
$2.2MDefining the Impact of E-Cigarettes on Cardiac PathophysiologyR01HL139348 · NHLBI · OHIO STATE UNIVERSITY · PI WOLD, LOREN EUGENE · 2017 to 2020
$1.9MSynergistic effects of obesity and air pollution on cardiac functionR01ES019923 · NIEHS · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI WOLD, LOREN EUGENE · 2011 to 2015
$1.8MNHLBI NIH HHS R01 HL139348NIA NIH HHS R01 AG057046NIEHS NIH HHS R01 ES019923NINR NIH HHS R01 NR012618
Abstract
backgroundParticulate matter (PM; PM METHODS AND
resultsFemale FVB mice were exposed either to filtered air or PM
conclusionsIn utero PM
Indexed as
Prenatal Exposure Delayed EffectsAction PotentialsAge FactorsAnimalsAnimals, NewbornArrhythmias, CardiacAtrial RemodelingCalcium-Binding ProteinsCalcium-Transporting ATPasesDNA (Cytosine-5-)-Methyltransferase 1DNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNA Methyltransferase 3BEpigenesis, GeneticFemaleGestational AgeCalcium-Binding ProteinsCalcium-Transporting ATPasesDNA (Cytosine-5-)-Methyltransferase 1DNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNA Methyltransferase 3BDnmt3a protein, mouseParticulate MatterPhospholambanSirt1 protein, mouseSirt2 protein, mouseSirtuin 1Sirtuin 2Sodium-Calcium Exchangerair pollutioncalcium signalingcardiaccardiovascular functionheart failurein uteromyocardialmyocyteparticulate matter
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.