ReviewTrends in molecular medicine2017
Cancer Manipulation of Host Physiology: Lessons from Pancreatic Cancer.
Review in Trends in molecular medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- The allosteric IDH1 inhibitor ivosidenib overcomes chemoresistance in intrahepatic cholangiocarcinoma models expressing wild-type IDH1.The Journal of clinical investigation · 2026Article
- UNITe: exploiting conserved links between oncogenesis and homeostasis to identify novel cancer drivers.Frontiers in oncology · 2026Article
- Clostridium butyricum and its metabolite butyrate promote ferroptosis susceptibility in pancreatic ductal adenocarcinoma.Cellular oncology (Dordrecht, Netherlands) · 2023Article
- The Liver Pre-Metastatic Niche in Pancreatic Cancer: A Potential Opportunity for Intervention.Cancers · 2022Review
- Circulating proteins and risk of pancreatic cancer: a case-subcohort study among Chinese adults.International journal of epidemiology · 2022Article
- Microbiome-Friend or Foe of Pancreatic Cancer?Journal of clinical medicine · 2021Review
- Targeting Glycolysis in Macrophages Confers Protection Against Pancreatic Ductal Adenocarcinoma.International journal of molecular sciences · 2021Article
- Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis.Nature communications · 2021Article
- TIPE2 Suppresses Malignancy of Pancreatic Cancer Through Inhibiting TGFβ1 Mediated Signaling Pathway.Frontiers in oncology · 2021Article
- Regulation and modulation of antitumor immunity in pancreatic cancer.Nature immunology · 2020Review
- Inflammation and tissue homeostasis: the NF-κB system in physiology and malignant progression.Molecular biology reports · 2020Review
- Blockade of Stromal Gas6 Alters Cancer Cell Plasticity, Activates NK Cells, and Inhibits Pancreatic Cancer Metastasis.Frontiers in immunology · 2020Article
- Characterization of genetic subclonal evolution in pancreatic cancer mouse models.Nature communications · 2019Article
- Effect of dexmedetomidine anesthesia on perioperative levels of TNF-α and IL-6 in patients with ovarian cancer.Oncology letters · 2019Article
- MyD88 signalling is critical in the development of pancreatic cancer cachexia.Journal of cachexia, sarcopenia and muscle · 2019Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Homeostasis is a fundamental property of living organisms enabling the human body to withstand internal and external insults. In several chronic diseases, and especially in cancer, many homeostatic mechanisms are deranged. Pancreatic cancer in particular is notorious for its ability to invoke an intense fibroinflammatory stromal reaction facilitating its progression and resistance to treatment. In the past decade, several seminal discoveries have elucidated previously unrecognized modes of commandeering the host's defense systems. Here we review novel discoveries in pancreatic cancer immunobiology and attempt to integrate the notion of deranged homeostasis in the pathogenesis of this disease. We also highlight areas of controversy and obstacles that need to be overcome, hoping to further our mechanistic insight into this malignancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.