Evidence map›Paper›PMID 28400210›Full record

ArticleJournal of molecular biology2017

Derepression of SaPIbov1 Is Independent of φNM1 Type 2 dUTPase Activity and Is Inhibited by dUTP and dUMP.

Rosanne L L Hill, Jiri Vlach, Laura K Parker, Gail E Christie, Jamil S Saad, Terje Dokland

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Is dUTPase Enzymatic Activity Truly Essential for Viability?International journal of molecular sciences · 2025
    Review
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  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Rosanne L L HillDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Jiri VlachDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Laura K ParkerDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA 23298, USA.
Gail E ChristieDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA 23298, USA.
Jamil S SaadDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Terje DoklandDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: dokland@uab.edu.
University of Alabama at Birmingham · USVirginia Commonwealth University · US

Funding

Structural basis for pathogenicity island mobilization in S. aureusR01AI083255 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DOKLAND, TERJE · 2009 to 2023
$5.6M
NIAID NIH HHS R01 AI083255
6 · The paper itself

Abstract

Staphylococcus aureus is an opportunistic human pathogen able to transfer virulence genes to other cells through the mobilization of S. aureus pathogenicity islands (SaPIs). SaPIs are derepressed and packaged into phage-like transducing particles by helper phages like 80α or φNM1. Phages 80α and φNM1 encode structurally distinct dUTPases, Dut

Indexed as

Genomic IslandsBacteriophagesDeoxyuracil NucleotidesEnzyme InhibitorsGene Knockout TechniquesHelper VirusesProtein BindingPyrophosphatasesRepressor ProteinsStaphylococcus aureus2'-deoxyuridylic acidDeoxyuracil Nucleotidesdeoxyuridine triphosphatedUTP pyrophosphataseEnzyme InhibitorsPyrophosphatasesRepressor Proteinsbacteriophagemolecular piracynuclear magnetic resonance (NMR)staphylococcal repressorStaphylococcus aureus pathogenicity island

Identifiers

PMID28400210
PMCPMC5509352
OpenAlexW2604350847

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.