Evidence map›Paper›PMID 28400089›Full record

ReviewTrends in cognitive sciences2017

Neural Noise Hypothesis of Developmental Dyslexia.

Roeland Hancock, Kenneth R Pugh, Fumiko Hoeft

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in cognitive sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 70 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  11. Translating the Power of Precision Medicine Into the World of Communication Disorders.Journal of speech, language, and hearing research : JSLHR · 2025
    Review
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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Roeland HancockDepartment of Psychiatry and Weill Institute for Neurosciences, University of California, San Francisco (UCSF), 401 Parnassus Ave. Box-0984, San Francisco, CA 94143, USA; Science-based Innovation in Learning Center (SILC), 401 Parnassus Ave. Box-0984, San Francisco, CA 94143, USA. Electronic address: roeland.hancock@ucsf.edu.
Kenneth R PughHaskins Laboratories, 300 George Street, New Haven, CT 06511, USA; Department of Linguistics, Yale University, 370 Temple Street, New Haven, CT 06520, USA; Department of Radiology and Biomedical Imaging, Yale University, 330 Cedar Street, New Haven, CT 06520, USA; Department of Psychological Sciences, University of Connecticut, 406 Babbidge Road, Storrs, CT 06269, USA.
Fumiko HoeftDepartment of Psychiatry and Weill Institute for Neurosciences, University of California, San Francisco (UCSF), 401 Parnassus Ave. Box-0984, San Francisco, CA 94143, USA; Haskins Laboratories, 300 George Street, New Haven, CT 06511, USA; Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160, Japan; Science-based Innovation in Learning Center (SILC), 401 Parnassus Ave. Box-0984, San Francisco, CA 94143, USA; Dyslexia Center, UCSF, 675 Nelson Rising Lane, San Francisco, CA 94158, USA. Electronic address: fumiko.hoeft@ucsf.edu.

Funding

Visual word identification: phonology &morphologyP01HD001994 · NICHD · HASKINS LABORATORIES, INC. · PI ZEVIN, JASON D · 1985 to 2016
$23.5M
Neurobiological predictors of spoken and written language learningR01HD065794 · NICHD · HASKINS LABORATORIES, INC. · PI PUGH, KENNETH R. · 2011 to 2015
$3.5M
Neurochemistry as a moderator of brain networks for readingR01HD086168 · NICHD · HASKINS LABORATORIES, INC. · PI HOEFT, FUMIKO, PUGH, KENNETH R. · 2016 to 2020
$3.2M
Understanding literacy acquisition through immersion in foreign languagesR01HD078351 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HENDREN, ROBERT LEE, HOEFT, FUMIKO · 2015 to 2020
$3.0M
NICHD NIH HHS P01 HD001994NICHD NIH HHS R01 HD065794NICHD NIH HHS R01 HD078351NICHD NIH HHS R01 HD086168
6 · The paper itself

Abstract

Developmental dyslexia (decoding-based reading disorder; RD) is a complex trait with multifactorial origins at the genetic, neural, and cognitive levels. There is evidence that low-level sensory-processing deficits precede and underlie phonological problems, which are one of the best-documented aspects of RD. RD is also associated with impairments in integrating visual symbols with their corresponding speech sounds. Although causal relationships between sensory processing, print-speech integration, and fluent reading, and their neural bases are debated, these processes all require precise timing mechanisms across distributed brain networks. Neural excitability and neural noise are fundamental to these timing mechanisms. Here, we propose that neural noise stemming from increased neural excitability in cortical networks implicated in reading is one key distal contributor to RD.

Indexed as

PhoneticsReadingAuditory PerceptionAuditory Perceptual DisordersDyslexiaHumansNoiseSpeech Perceptionexcitabilityglutamateneural oscillationneurogeneticsreading

Identifiers

PMID28400089
PMCPMC5489551

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.