ArticleThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2017
Implementing isoniazid preventive therapy in a tuberculosis treatment-experienced cohort on ART.
Article in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Loss to follow-up among people living with HIV on tuberculosis preventive treatment at four regional referral hospitals, Uganda, 2019-2021.Journal of clinical tuberculosis and other mycobacterial diseases · 2024Article
- Article
- Article
- Community-based referral for tuberculosis preventive therapy is effective for treatment completion.PLOS global public health · 2022Article
- Assessment of the tuberculosis case-finding and prevention cascade among people living with HIV in Zambia - 2018: a cross-sectional cluster survey.BMC public health · 2021Article
- AFrontiers in immunology · 2021Article
- Evaluation of the uptake of tuberculosis preventative therapy for people living with HIV in Namibia: a multiple methods analysis.BMC public health · 2020Article
- Determinants of isoniazid preventive therapy completion among people living with HIV attending care and treatment clinics from 2013 to 2017 in Dar es Salaam Region, Tanzania. A cross-sectional analytical study.BMC infectious diseases · 2020Article
- Outcomes of isoniazid preventive therapy among people living with HIV in Kenya: A retrospective study of routine health care data.PloS one · 2020Article
- Quality of TB care among people living with HIV: Gaps and solutions.Journal of clinical tuberculosis and other mycobacterial diseases · 2019Review
- Long-term adherence to antiretroviral therapy in a South African adult patient cohort: a retrospective study.BMC infectious diseases · 2019Article
- Detection of Tuberculosis Recurrence, Diagnosis and Treatment Response by a Blood Transcriptomic Risk Signature in HIV-Infected Persons on Antiretroviral Therapy.Frontiers in microbiology · 2019Article
- Isoniazid preventive therapy: Uptake, incidence of tuberculosis and survival among people living with HIV in Bulawayo, Zimbabwe.PloS one · 2019Article
- Implementation of Isoniazid Preventive Therapy among People Living with HIV in Northwestern Nigeria: Completion Rate and Predictive Factors.Journal of global infectious diseasesArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
settingUrban clinical research site in Durban, South Africa.
objectiveTo describe outcomes associated with the implementation of isoniazid preventive therapy (IPT) in a cohort of tuberculosis (TB) treatment-experienced human immunodeficiency virus (HIV) infected patients on antiretroviral therapy (ART).
designWe conducted a secondary analysis of data collected between October 2009 and October 2013 from patients enrolled in a prospective cohort study conducted in Durban, South Africa.
resultsOf the 402 patients enrolled in the parent study, 344 (85.6%) were eligible for IPT, 212 of whom (61.6%) initiated IPT. Of those who initiated IPT, 184 (86.8%) completed the 6-month course, while 24 (11.3%) permanently discontinued IPT, 3.8% of whom due to side effects. More women than men initiated IPT (n = 130, 61.3% vs. n = 82, 38.7%, P = 0.001). Overall median adherence to IPT was 97.6% (interquartile range 94.2-99.4). There were 22 cases of incident TB in this cohort: 13 occurred before IPT and 9 after (incidence rate ratio 0.67, 95%CI 0.29-1.58, P = 0.362).
conclusionsIPT implementation among ART and TB treatment-experienced patients was well tolerated, with good completion rates and fewer TB cases diagnosed after IPT.
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