ArticleWorld journal of surgical oncology2017
Early closure of defunctioning stoma increases complications related to stoma closure after concurrent chemoradiotherapy and low anterior resection in patients with rectal cancer.
Article in World journal of surgical oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- The effect of telemedicine on stoma-related complications in adults with enterostomy: A systematic review and meta-analysis.International wound journal · 2024Pooled it
- Overall readmissions and readmissions related to dehydration after creation of an ileostomy: a systematic review and meta-analysis.Techniques in coloproctology · 2022Pooled it
- Systematic review and meta-analysis of incisional hernia post-reversal of ileostomy.Hernia : the journal of hernias and abdominal wall surgery · 2020Pooled it
- Quality of life following ostomy reversal with purse-string vs linear skin closure: a systematic review.International journal of colorectal disease · 2019Pooled it
- Effect and influencing factors of early ileostomy closure 2-4 weeks on patients with rectal cancer.Frontiers in oncology · 2026Article
- Early vs. Late Stoma Reversal After Open Low Anterior Resection Post-Neoadjuvant Chemoradiotherapy.Indian journal of surgical oncology · 2025Article
- Early versus conventional closure of intestinal stoma: Insights from a tertiary care hospital in India.Bioinformation · 2025Article
- Impact of the Timing of Protective Stoma Reversal on Survival in Rectal Cancer Patients Undergoing Postoperative Adjuvant Chemotherapy: A Retrospective Single Center Study.Cancer management and research · 2025Article
- Complications associated with loop ileostomy reversal delayed greater than twelve months.Scientific reports · 2024Article
- Long term persistence and risk factors for anorectal symptoms following low anterior resection for rectal cancer.BMC gastroenterology · 2024Article
- Evaluation of the SafeHeal Colovac+ anastomosis protection device after low anterior resection for rectal cancer: the safe anastomosis feasibility evaluation (SAFE) 2019 trial.Surgical endoscopy · 2023Article
- Defunctioning stoma in anterior resection for rectal cancer does not impact anastomotic leakage: a national population-based cohort study.BMC surgery · 2023Article
- Efficacy of concurrent radiotherapy in patients with locally advanced rectal cancer and synchronous metastasis receiving systemic therapy.Frontiers in oncology · 2023Article
- Tailored Management with Highly-Selective Diversion for Low Colorectal Anastomosis: Biochemical Postoperative Follow-Up and Long-Term Results from a Single-Institution Cohort.Annals of surgical oncology · 2022Article
- Predictors of morbidity related to stoma closure after colorectal cancer surgery.Langenbeck's archives of surgery · 2021Article
- The safety of early versus late ileostomy reversal after low anterior rectal resection: a retrospective study in 47 patients.Patient safety in surgery · 2021Article
- No Coil® placement in patients undergoing left hemicolectomy and low anterior resection for colorectal cancer.World journal of surgical oncology · 2020Article
- Intraluminal flexible sheath for the protection of low anastomosis after anterior resection: results from a First-In-Human trial on 15 patients.Surgical endoscopy · 2020Article
- Diverting Ileostomy Duration Is the Main Determinant of Ileostomy-Related Complications after Surgical Treatment of Rectum Cancer.Journal of oncology · 2020Article
- Early ileostomy reversal after minimally invasive surgery and ERAS program for mid and low rectal cancer.Updates in surgery · 2019Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAfter a low anterior resection, creating a defunctioning stoma is vital for securing the anastomosis in low-lying rectal cancer patients receiving concurrent chemoradiotherapy. Although it decreases the complication and reoperation rates associated with anastomotic leakage, the complications that arise before and after stoma closure should be carefully evaluated and managed.
methodsThis study enrolled 95 rectal cancer patients who received neoadjuvant concurrent chemoradiotherapy and low anterior resection with anastomosis of the bowel between July 2010 and November 2012. A defunctioning stoma was created in 63 patients during low anterior resection and in another three patients after anastomotic leakage.
resultsThe total complication rate from stoma creation to closure was 36.4%. Ileostomy led to greater renal insufficiency than colostomy did and significantly increased the readmission rate (all p < 0.05). The complication rate related to stoma closure was 36.0%. Patients with ileostomy had an increased risk of developing complications (p = 0.017), and early closure of the defunctioning stoma yielded a higher incidence of morbidity (p = 0.006). Multivariate analysis revealed that a time to closure of ≤109 days was an independent risk factor for developing complications (p = 0.007).
conclusionsThe optimal timing of stoma reversal is at least 109 days after stoma construction in rectal cancer patients receiving concurrent chemoradiotherapy and low anterior resection.
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