Evidence map›Paper›PMID 28399865›Full record

ArticleJournal of nanobiotechnology2017

Toxicity of nano- and ionic silver to embryonic stem cells: a comparative toxicogenomic study.

Xiugong Gao, Vanessa D Topping, Zachary Keltner, Robert L Sprando, Jeffrey J Yourick

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 53 citations in OpenAlex.

  1. Green Synthesis of Silver Nanoparticles fromMolecules (Basel, Switzerland) · 2025
    Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Zn-Incorporated TiOInternational journal of nanomedicine · 2020
    Article
  15. Review
  16. Review
  17. Toxicogenomics: A 2020 Vision.Trends in pharmacological sciences · 2019
    Review
  18. Anti-Methicillin-ResistantFrontiers in pharmacology · 2019
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xiugong GaoDivision of Applied Regulatory Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD, 20708, USA. Xiugong.Gao@fda.hhs.gov.
Vanessa D ToppingDivision of Applied Regulatory Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD, 20708, USA.
Zachary KeltnerDivision of Applied Regulatory Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD, 20708, USA.
Robert L SprandoDivision of Applied Regulatory Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD, 20708, USA.
Jeffrey J YourickDivision of Applied Regulatory Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD, 20708, USA.
Center for Food Safety and Applied Nutrition · USUnited States Food and Drug Administration · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe widespread application of silver nanoparticles (AgNPs) and silver-containing products has raised public safety concerns about their adverse effects on human health and the environment. To date, in vitro toxic effects of AgNPs and ionic silver (Ag

resultsThe present study characterized transcriptomic changes induced by 5.0 µg/ml AgNPs during spontaneous differentiation of mouse ESCs, and compared them to those induced by Ag

conclusionsTaken together, the results presented in the current study demonstrate that both AgNPs and Ag

Indexed as

AnimalsApoptosisCell DifferentiationCell LineEmbryonic Stem CellsIonsMass SpectrometryMetal NanoparticlesMiceMicroscopy, Electron, TransmissionOxidative StressParticle SizeSilverToxicogeneticsTranscriptomeIonsSilverDevelopmental toxicityEmbryonic stem cellSilver ionSilver nanoparticlesTranscriptomics

Identifiers

PMID28399865
PMCPMC5387260
OpenAlexW2607079828

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.