Evidence map›Paper›PMID 28399564›Full record

ArticleAmerican journal of epidemiology2017

Interactions Between Genome-Wide Significant Genetic Variants and Circulating Concentrations of 25-Hydroxyvitamin D in Relation to Prostate Cancer Risk in the National Cancer Institute BPC3.

Vasiliki I Dimitrakopoulou, Ruth C Travis, Irene M Shui, Alison Mondul, Demetrius Albanes, Jarmo Virtamo, Antonio Agudo, Heiner Boeing, H Bas Bueno-de-Mesquita, Marc J Gunter and 18 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. A Systematic Analysis of Interactions between Environmental Risk Factors and Genetic Variation in Susceptibility to Colorectal Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020
    Article
  6. Article
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 19 institutions in 12 countries.

Vasiliki I DimitrakopoulouDepartment of Hygiene and Epidemiology, University of Ioannina School of Medicine, Stavros Niarchos Avenue, University Campus, Ioannina, Greece
Ruth C TravisCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
Irene M ShuiDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Alison MondulDepartment of Epidemiology,University of Michigan School of Public Health,Ann Arbor, MI,USA.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.
Jarmo VirtamoNational Institute for Health and Welfare (THL), Helsinki, Finland.
Antonio AgudoCatalan Institute of Oncology (ICO), Barcelona, Spain.
Heiner BoeingDepartment of Epidemiology,German Institute of Human Nutrition Potsdam-Rehbruecke,14558 Nuthetal,Germany.
H Bas Bueno-de-MesquitaSchool of Public Health, Imperial College London, London, United Kingdom.
Marc J GunterInternational Agency for Research on Cancer (IARC-WHO), Lyon, France.
Mattias JohanssonDepartment of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, 750 07, Uppsala, SE, Sweden.
Kay-Tee KhawDepartment of Public Health and Primary Care, University of Cambridge, UK.
Kim OvervadDepartment of Public Health, Section for Epidemiology, Aarhus University, Bartholins Allé 2, 8000, Aarhus C, Denmark.
Domenico PalliCancer Risk Factors and Life-Style Epidemiology Unit,Cancer Research and Prevention Institute (ISPO),50141 Florence,Italy.
Antonia TrichopoulouHellenic Health Foundation,GR-115 27, Athens,Greece.
Edward GiovannucciChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA.
David J HunterDepartment of Rheumatology, Royal North Shore Hospital, Sydney, New South Wales, Australia.
Sara LindströmDepartment of Epidemiology, University of Washington
Walter WillettChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA.
J Michael GazianoAging, Brigham and Women's Hospital, Boston, MA.
Meir StampferDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
Christine BergDepartment of Obstetrics and Prenatal Medicine, University of Bonn, Bonn, Germany.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Amanda BlackMidwest Orthopaedics at Rush, Rush University Medical Center, Chicago, Illinois, USA.
Robert N HooverDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.
Peter KraftUniversity of Washington and Harvard T.H. Chan School of Public Health, WA, USA.
Timothy J KeyCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Konstantinos K TsilidisSchool of Public Health, Imperial College London, London, United Kingdom.
Brigham and Women's Hospital · USImperial College London · GBNational Institutes of Health · USUniversity of Oxford · GBAarhus University · DKCentre International de Recherche sur le Cancer · FRFinnish Institute for Health and Welfare · FIFred Hutch Cancer Center · USHarvard University · USInstitut Català d'Ornitologia · ESNational Cancer Institute · USRush University Medical Center · USSwedish University of Agricultural Sciences · SEUniversity of Bonn · DEUniversity of Cambridge · GBUniversity of Ioannina · GRUniversity of Sydney · AUUniversity of Washington · USVA Boston Healthcare System · US

Funding

Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) StudyZIACP010195 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ALBANES, DEMETRIUS · 2009 to 2025
$22.5M
Characterizing Genetic Susceptibility to Breast and Prostate Cancer; the BPC3U01CA098758 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2003 to 2010
$11.0M
Characterizing Genetic Susceptibility to Breast and Prostate Cancer; the BPC3U01CA098233 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HUNTER, DAVID JOHN · 2003 to 2010
$10.8M
Characterizing Genetic Susceptibility to Breast and Prostate Cancer; the BPC3U01CA098216 · NCI · INTERNATIONAL AGENCY FOR RES ON CANCER · PI RIBOLI, ELIO · 2003 to 2011
$7.4M
Characterizing Genetic Susceptibility to Breast and Prostate Cancer: The BPC3.U01CA098710 · NCI · AMERICAN CANCER SOCIETY, INC. · PI GAPSTUR, SUSAN M · 2003 to 2011
$4.2M
Cancer Research UK 14136Cancer Research UK 16491Cancer Research UK 19170Medical Research Council G0401527Medical Research Council G1000143Medical Research Council MR/N003284/1NCI NIH HHS U01 CA098216NCI NIH HHS U01 CA098233NCI NIH HHS U01 CA098710NCI NIH HHS U01 CA098758World Health Organization 001
6 · The paper itself

Abstract

Genome-wide association studies (GWAS) have identified over 100 single nucleotide polymorphisms (SNPs) associated with prostate cancer. However, information on the mechanistic basis for some associations is limited. Recent research has been directed towards the potential association of vitamin D concentrations and prostate cancer, but little is known about whether the aforementioned genetic associations are modified by vitamin D. We investigated the associations of 46 GWAS-identified SNPs, circulating concentrations of 25-hydroxyvitamin D (25(OH)D), and prostate cancer (3,811 cases, 511 of whom died from the disease, compared with 2,980 controls-from 5 cohort studies that recruited participants over several periods beginning in the 1980s). We used logistic regression models with data from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3) to evaluate interactions on the multiplicative and additive scales. After allowing for multiple testing, none of the SNPs examined was significantly associated with 25(OH)D concentration, and the SNP-prostate cancer associations did not differ by these concentrations. A statistically significant interaction was observed for each of 2 SNPs in the 8q24 region (rs620861 and rs16902094), 25(OH)D concentration, and fatal prostate cancer on both multiplicative and additive scales (P ≤ 0.001). We did not find strong evidence that associations between GWAS-identified SNPs and prostate cancer are modified by circulating concentrations of 25(OH)D. The intriguing interactions between rs620861 and rs16902094, 25(OH)D concentration, and fatal prostate cancer warrant replication.

Indexed as

Gene-Environment InteractionGenome-Wide Association StudyAgedCase-Control StudiesGenotypeHumansLogistic ModelsMaleMiddle AgedPolymorphism, Single NucleotideProstatic NeoplasmsProtective FactorsRisk AssessmentVitamin D25-hydroxyvitamin DVitamin D25-hydroxyvitamin DBPC3gene-environment interactionsgenome-wide association studiesprostate cancer

Identifiers

PMID28399564
PMCPMC5856084
OpenAlexW2589459138

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.