Evidence map›Paper›PMID 28399394›Full record

ReviewDevelopmental cell2017

Cleaning House: Selective Autophagy of Organelles.

Allyson L Anding, Eric H Baehrecke

Abstract readReview
In one paragraph

Review in Developmental cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 336 papers.

0numbers the graph read from it
0cells of the map it votes in
336citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

336 citing papers in PubMed.

  1. Atg39-dependent nucleophagy and Atg40-dependent ER-phagy require the Apq12/Brr6/Brl1 complex.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Eccentric Exercise and Muscle Damage: An Introductory Guide.Journal of functional morphology and kinesiology · 2026
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Autophagy in the liver.Autophagy reports · 2026
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Developing Endogenous Autophagy Reporters inInternational journal of molecular sciences · 2025
    Article
  17. The Biological Role and Clinical Significance of BECLIN-1 in Cancer.International journal of molecular sciences · 2025
    Review
  18. Article
  19. Atg9 is a conserved regulator of lysosome repair.The Journal of cell biology · 2025
    Article
  20. Review

276 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Allyson L AndingDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Eric H BaehreckeDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: eric.baehrecke@umassmed.edu.

Funding

Genetic Regulation of Autophagic Cell DeathR01GM079431 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BAEHRECKE, ERIC H · 2007 to 2019
$4.4M
Characterization of a novel autophagy pathwayR01GM111658 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BAEHRECKE, ERIC H · 2015 to 2018
$1.3M
NIGMS NIH HHS R01 GM079431NIGMS NIH HHS R01 GM111658
6 · The paper itself

Abstract

The selective clearance of organelles by autophagy is critical for the regulation of cellular homeostasis in organisms from yeast to humans. Removal of damaged organelles clears the cell of potentially toxic byproducts and enables reuse of organelle components for bioenergetics. Thus, defects in organelle clearance may be detrimental to the health of the cells, contributing to cancer, neurodegeneration, and inflammatory diseases. Organelle-specific autophagy can clear mitochondria, peroxisomes, lysosomes, ER, chloroplasts, and the nucleus. Here, we review our understanding of the mechanisms that regulate the clearance of organelles by autophagy and highlight gaps in our knowledge of these processes.

Indexed as

AutophagyAnimalsHumansMitophagyModels, BiologicalOrganellesautophagychlorophagyER-phagylysophagymitophagynucleophagypexophagy

Identifiers

PMID28399394
PMCPMC5395098

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.