ArticleAge and ageing2017
Associations of fat and muscle tissue with cognitive status in older adults: the AGES-Reykjavik Study.
Article in Age and ageing, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 62 citations in OpenAlex.
- Liraglutide improves memory in obese patients with prediabetes or early type 2 diabetes: a randomized, controlled study.International journal of obesity (2005) · 2020Trial
- Association between visceral adiposity index and incident dementia: a community-based cohort study.BMC psychiatry · 2026Article
- Is Adipose Tissue Inflammation the Culprit of Obesity-Associated Comorbidities?Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- Development and multi-center validation of a high-performance predictive model for early detection of cognitive impairment in older adults: data-based on communities in Northern China.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Abdominal myosteatosis is associated with lower processing speed in a multiethnic cohort of older adults.Archives of gerontology and geriatrics · 2025Article
- Fat mass in postmenopausal women with osteoporosis is associated with cognitive function.Scientific reports · 2025Article
- Plasma proteomic analysis of intermuscular fat links muscle integrity with processing speed in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The association between metabolic syndrome components and cognitive function in community-dwelling middle-aged and older adults: the first wave result of a cohort study.Journal of health, population, and nutrition · 2025Article
- Relationship between obesity indices and cognitive function in Japanese men: A cross-sectional study.PloS one · 2025Article
- Impact of visceral adiposity index on cognitive impairment and cognitive trajectories in Chinese middle-aged and older adults.Frontiers in public health · 2025Article
- Correlation between fat-to-muscle mass ratio and cognitive impairment in elderly patients with type 2 diabetes mellitus: a cross-sectional study.BMC geriatrics · 2024Article
- Association between abdominal adiposity and cognitive decline in older adults: a 10-year community-based study.The journal of nutrition, health & aging · 2024Article
- Article
- Increase in skeletal muscular adiposity and cognitive decline in a biracial cohort of older men and women.Journal of the American Geriatrics Society · 2023Article
- Poor Cognitive Agility Conservation in Obese Aging People.Biomedicines · 2023Article
- Predicted lean body mass in relation to cognitive function in the older adults.Frontiers in endocrinology · 2023Article
- The association between regional adiposity, cognitive function, and dementia-related brain changes: a systematic review.Frontiers in medicine · 2023Review
- Recent Updates on Associations among Various Obesity Metrics and Cognitive Impairment: from Body Mass Index to Sarcopenic Obesity.Journal of obesity & metabolic syndrome · 2022Review
- Obesity marker trajectories and cognitive impairment in older adults: a 10-year follow-up in Taichung community health study for elders.BMC psychiatry · 2022Article
- The Impact of the COVID-19 Pandemic and Social Distancing on Cognition of Alzheimer's Disease Patients.Psychiatry investigation · 2022Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
Background/Objective: studies on the association of dementia with specific body composition (BC) components are scarce. Our aim was to investigate associations of BC measures with different levels of cognitive function in late-life. Methods: we studied 5,169 participants (mean age 76 years, 42.9% men) in the AGES-Reykjavik Study of whom 485 (9.4%) were diagnosed with mild cognitive impairment (MCI) and 307 (5.9%) with dementia. Visceral fat, abdominal and thigh subcutaneous fat, and thigh muscle were assessed by computed tomography. MCI and dementia were based on clinical assessment and a consensus meeting; those without MCI or dementia were categorised as normal. Multinomial regression models assessed the associations stratified by sex and in additional analyses by midlife body mass index (BMI). Results: among women, there was a decreased likelihood of dementia per SD increase in abdominal subcutaneous fat (OR 0.72; 95% CI: 0.59-0.88), thigh subcutaneous fat (0.81; 0.67-0.98) and thigh muscle (0.63; 0.52-0.76), but not visceral fat, adjusting for demographics, vascular risk factors, stroke and depression. Inverse associations of fat with dementia were attenuated by weight change from midlife and were strongest in women with midlife BMI <25. In men, one SD increase in thigh muscle was associated with a decreased likelihood of dementia (0.75; 0.61-0.92). BC was not associated with MCI in men or women. Conclusion: a higher amount of abdominal and thigh subcutaneous fat were associated with a lower likelihood of dementia in women only, while more thigh muscle was associated with a lower likelihood of dementia in men and women.
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