ArticlePloS one2017
Hydrophobic pinning with copper nanowhiskers leads to bactericidal properties.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Mechanical Properties of Cu+CuO Coatings Determined by Nanoindentation and Laugier Model.Materials (Basel, Switzerland) · 2025Article
- Physico-Chemical Properties of Copper-Doped Hydroxyapatite Coatings Obtained by Vacuum Deposition Technique.Materials (Basel, Switzerland) · 2024Article
- Recent Advances in Whiskers: Properties and Clinical Applications in Dentistry.International journal of nanomedicine · 2024Review
- Differential Analysis of Three Copper-Based Nanomaterials with Different Morphologies to SuppressInternational journal of molecular sciences · 2023Article
- Designing Effective Antimicrobial Nanostructured Surfaces: Highlighting the Lack of Consensus in the Literature.ACS omega · 2023Review
- Effect of Passive Ultrasonic Irrigation, Er,Cr:YSGG Laser, and Photon-Induced Photoacoustic Streaming againstBioengineering (Basel, Switzerland) · 2023Article
- Antibacterial and Proliferative Effects of NaOH-Coated Titanium, Zirconia, and Ceramic-Reinforced PEEK Dental Composites on Bone Marrow Mesenchymal Stem Cells.Pharmaceutics · 2022Article
- Article
- Multi-Stimulus Responsive Multilayer Coating for Treatment of Device-Associated Infections.Journal of functional biomaterials · 2022Article
- Antibacterial Effect of Functionalized Polymeric Nanoparticles on Titanium Surfaces Using an In Vitro Subgingival Biofilm Model.Polymers · 2022Article
- Copper Surfaces in Biofilm Control.Nanomaterials (Basel, Switzerland) · 2020Review
- Artificial Intelligence Aided Design of Microtextured Surfaces: Application to Controlling Wettability.Nanomaterials (Basel, Switzerland) · 2020Article
- Biofilm Formation and Expression of Virulence Genes of Microorganisms Grown in Contact with a New Bioactive Glass.Pathogens (Basel, Switzerland) · 2020Article
- In Vivo Biocompatibility of Electrospun Biodegradable Dual Carrier (Antibiotic + Growth Factor) in a Mouse Model-Implications for Rapid Wound Healing.Pharmaceutics · 2019Article
- Redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review.Cell death & disease · 2018Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The considerable morbidity associated with hospitalized patients and clinics in developed countries due to biofilm formation on biomedical implants and surgical instruments is a heavy economic burden. An alternative to chemically treated surfaces for bactericidal activity started emerging from micro/nanoscale topographical cues in the last decade. Here, we demonstrate a putative antibacterial surface using copper nanowhiskers deposited by molecular beam epitaxy. Furthermore, the control of biological response is based on hydrophobic pinning of water droplets in the Wenzel regime, causing mechanical injury and cell death. Scanning electron microscopy images revealed the details of the surface morphology and non-contact mode laser scanning of the surface revealed the microtopography-associated quantitative parameters. Introducing the bacterial culture over nanowhiskers produces mechanical injury to cells, leading to a reduction in cell density over time due to local pinning of culture medium to whisker surfaces. Extended culture to 72 hours to observe biofilm formation revealed biofilm inhibition with scattered microcolonies and significantly reduced biovolume on nanowhiskers. Therefore, surfaces patterned with copper nanowhiskers can serve as potential antibiofilm surfaces. The topography-based antibacterial surfaces introduce a novel prospect in developing mechanoresponsive nanobiomaterials to reduce the risk of medical device biofilm-associated infections, contrary to chemical leaching of copper as a traditional bactericidal agent.
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