ArticlePloS one2017
Collinear Hox-Hox interactions are involved in patterning the vertebrate anteroposterior (A-P) axis.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Human colon organoid differentiation from induced pluripotent stem cells using an improved method.FEBS letters · 2025Article
- Patterning of the Vertebrate Head in Time and Space by BMP Signaling.Journal of developmental biology · 2023Article
- Spatiotemporal transcriptomic maps of whole mouse embryos at the onset of organogenesis.Nature genetics · 2023Article
- Developmental disruption and restoration of brain synaptome architecture in the murine Pax6 neurodevelopmental disease model.Nature communications · 2022Article
- Patterning with clocks and genetic cascades: Segmentation and regionalization of vertebrate versus insect body plans.PLoS genetics · 2021Review
- Physical Laws Shape Up HOX Gene Collinearity.Journal of developmental biology · 2021Review
- Elevated Hoxb5b Expands Vagal Neural Crest Pool and Blocks Enteric Neuronal Development in Zebrafish.Frontiers in cell and developmental biology · 2021Article
- A Tribute to Lewis Wolpert and His Ideas on the 50th Anniversary of the Publication of His Paper 'Positional Information and the Spatial Pattern of Differentiation'. Evidence for a Timing Mechanism for Setting Up the Vertebrate Anterior-Posterior (A-P) Axis.International journal of molecular sciences · 2020Review
- What are the roles of retinoids, other morphogens, and Hox genes in setting up the vertebrate body axis?Genesis (New York, N.Y. : 2000) · 2019Review
- Vertebrate hox temporal collinearity: does it exist and what is it's function?Cell cycle (Georgetown, Tex.) · 2019Review
- Some Questions and Answers About the Role ofFrontiers in cell and developmental biology · 2019Article
- Two Tier Hox Collinearity Mediates Vertebrate Axial Patterning.Frontiers in cell and developmental biology · 2018Article
- Article
- Hoxc6 loss of function truncates the main body axis in Xenopus.Cell cycle (Georgetown, Tex.) · 2017Article
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3 authors.
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Abstract
Investigating regulation and function of the Hox genes, key regulators of positional identity in the embryo, opened a new vista in developmental biology. One of their most striking features is collinearity: the temporal and spatial orders of expression of these clustered genes each match their 3' to 5' order on the chromosome. Despite recent progress, the mechanisms underlying collinearity are not understood. Here we show that ectopic expression of 4 different single Hox genes predictably induces and represses expression of others, leading to development of different predictable specific sections of the body axis. We use ectopic expression in wild-type and noggin-dorsalised (Hox-free) Xenopus embryos, to show that two Hox-Hox interactions are important. Posterior induction (induction of posterior Hox genes by anterior ones: PI), drives Hox temporal collinearity (Hox timer), which itself drives anteroposterior (A-P) patterning. Posterior prevalence (repression of anterior Hox genes by posterior ones: PP) is important in translating temporal to spatial collinearity. We thus demonstrate for the first time that two collinear Hox interactions are important for vertebrate axial patterning. These findings considerably extend and clarify earlier work suggesting the existence and importance of PP and PI, and provide a major new insight into genesis of the body axis.
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