ReviewCurrent opinion in nephrology and hypertension2017
Pathophysiology and implications of intradialytic hypertension.
Review in Current opinion in nephrology and hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- I Brazilian guideline on hypertension in dialysis of the Brazilian Society of Nephrology.Jornal brasileiro de nefrologiaGuideline
- Effects of spironolactone on intradialytic hypertension: a multicentre, double-blind, randomized, crossover study.Clinical kidney journal · 2025Article
- Intradialytic Hypertension in Maintenance Hemodialysis.Current hypertension reports · 2024Review
- Randomized Trial on the Effects of Dialysate Potassium Concentration on Intradialytic Hypertension.Kidney international reports · 2023Article
- Antihypertensive Medications Use among Chronic Hemodialysis Patients Visiting the Outpatient Department of Nephrology of a Tertiary Care Centre: A Descriptive Cross-sectional Study.JNMA; journal of the Nepal Medical Association · 2023Article
- Article
- Intradialytic hypertension: epidemiology and pathophysiology of a silent killer.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Review
- Correlation of Nursing Quality and Complications in the Hemodialysis Room as well as Nursing Countermeasures.Journal of healthcare engineering · 2022Article
- Intradialysis hypotension and hypertension in patients with end stage kidney disease in Nigeria: risk factors and clinical correlates.Ghana medical journal · 2021Article
- Management of acute intradialytic cardiovascular complications: Updated overview (Review).Experimental and therapeutic medicine · 2021Review
- Review of Traditional Chinese Medicines for Common Complications Related to Hemodialysis: An Evidence-Based Perspective.Evidence-based complementary and alternative medicine : eCAM · 2021Review
- Ischemic heart disease cause of intradialytic hypertension in a patient with diabetic nephropathy.Journal of cardiology cases · 2020Article
- Augmented Cardiopulmonary Baroreflex Sensitivity in Intradialytic Hypertension.Kidney international reports · 2018Article
- The Association between Intradialytic Hypertension and Metabolic Disorders in End Stage Renal Disease.International journal of hypertension · 2018Article
- Hypertension in patients on dialysis: diagnosis, mechanisms, and management.Jornal brasileiro de nefrologiaReview
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
purpose of reviewIntradialytic hypertension occurs regularly in 10--15% of hemodialysis patients. A large observational study recently showed that intradialytic hypertension of any magnitude increased mortality risk comparable to the most severe degrees of intradialytic hypotension. The present review review discusses the most recent evidence underlying the pathophysiology of intradialytic hypertension and implications for its management. RECENT
findingsPatients with intradialytic hypertension typically have small interdialytic weight gains, but bioimpedance spectroscopy shows these patients have significant chronic extracellular volume excess. Intradialytic hypertension patients have lower albumin and predialysis urea nitrogen levels, which may contribute to small reductions in osmolarity that prevents blood pressure decreases. Intradialytic vascular resistance surges remain implicated as the driving force for blood pressure increases, but mediators other than endothelin-1 may be responsible. Beyond dry weight reduction, the only controlled intervention shown to interrupt the blood pressure increase is lowering dialysate sodium. SUMMARY: Patients with recurrent intradialytic hypertension should be identified as high-risk patients. Dry weight should be re-evaluated, even if patients do not clinically appear volume overloaded. Antihypertensive drugs should be prescribed because of the persistently elevated ambulatory blood pressure. Dialysate sodium reduction should be considered, although the long term effects of this intervention are uncertain.
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Registered trials
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