ArticleMenopause (New York, N.Y.)2017
Physiologically assessed hot flashes and endothelial function among midlife women.
Article in Menopause (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Very-low-calorie ketogenic diet (VLCKD) in the management of metabolic diseases: systematic review and consensus statement from the Italian Society of Endocrinology (SIE).Journal of endocrinological investigation · 2019Pooled it
- Effect of Exercise Modalities on Post-Exercise Hypotension in Normotensive Postmenopausal Women: A Randomized Controlled Trial on Vasomotor Symptoms Influence.European journal of sport science · 2025Trial
- SLCO1B1 genetic variation and hormone therapy in menopausal women.Menopause (New York, N.Y.) · 2018Trial
- Microvascular endothelial function is blunted in postmenopausal females with frequent hot flushes.Experimental physiology · 2026Article
- Physical activity moderates the relationship between hot flashes and arterial wave reflection in perimenopausal females.Physiological reports · 2026Article
- Feeling Like a Woman: Interoception and the Objectified Body.Brain sciences · 2026Review
- Higher amounts of habitual physical activity changes the relationship between hot flashes and subclinical cardiovascular disease risk.Physiological reports · 2025Article
- The menopausal transition period and cardiovascular risk.Nature reviews. Cardiology · 2024Review
- Vasomotor symptoms and cardiovascular health: findings from the SWAN and the MsHeart/MsBrain studies.Climacteric : the journal of the International Menopause Society · 2024Review
- Menopausal Vasomotor Symptoms and Risk of Incident Cardiovascular Disease Events in SWAN.Journal of the American Heart Association · 2021 · on this mapArticle
- Impact of nulliparity, hypertensive disorders of pregnancy, and gestational diabetes on vasomotor symptoms in midlife women.Menopause (New York, N.Y.) · 2020Article
- Life-Course Reproductive History and Cardiovascular Risk Profile in Late Mid-Life: The CARDIA Study.Journal of the American Heart Association · 2020Article
- Associations of Endogenous Sex Hormones with Carotid Plaque Burden and Characteristics in Midlife Women.The Journal of clinical endocrinology and metabolism · 2020Article
- Vasomotor Symptoms and Accelerated Epigenetic Aging in the Women's Health Initiative (WHI).The Journal of clinical endocrinology and metabolism · 2020 · on this mapObservational
- Menopause and Brain Health: Hormonal Changes Are Only Part of the Story.Frontiers in neurology · 2020Review
- Longitudinal course of vasomotor symptoms in perimenopausal migraineurs.Annals of neurology · 2019Article
- A sensitive and robust UPLC-MS/MS method for quantitation of estrogens and progestogens in human serum.Contraception · 2019Article
- Article
- What's in a name: are menopausal "hot flashes" a symptom of menopause or a manifestation of neurovascular dysregulation?Menopause (New York, N.Y.) · 2018Article
- Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveHot flashes are experienced by most midlife women. Emerging data indicate that they may be associated with endothelial dysfunction. No studies have tested whether hot flashes are associated with endothelial function using physiologic measures of hot flashes. We tested whether physiologically assessed hot flashes were associated with poorer endothelial function. We also considered whether age modified associations.
methodsTwo hundred seventy-two nonsmoking women reporting either daily hot flashes or no hot flashes, aged 40 to 60 years, and free of clinical cardiovascular disease, underwent ambulatory physiologic hot flash and diary hot flash monitoring; a blood draw; and ultrasound measurement of brachial artery flow-mediated dilation to assess endothelial function. Associations between hot flashes and flow-mediated dilation were tested in linear regression models controlling for lumen diameter, demographics, cardiovascular disease risk factors, and estradiol.
resultsIn multivariable models incorporating cardiovascular disease risk factors, significant interactions by age (P < 0.05) indicated that among the younger tertile of women in the sample (age 40-53 years), the presence of hot flashes (beta [standard error] = -2.07 [0.79], P = 0.01), and more frequent physiologic hot flashes (for each hot flash: beta [standard error] = -0.10 [0.05], P = 0.03, multivariable) were associated with lower flow-mediated dilation. Associations were not accounted for by estradiol. Associations were not observed among the older women (age 54-60 years) or for self-reported hot flash frequency, severity, or bother. Among the younger women, hot flashes explained more variance in flow-mediated dilation than standard cardiovascular disease risk factors or estradiol.
conclusionsAmong younger midlife women, frequent hot flashes were associated with poorer endothelial function and may provide information about women's vascular status beyond cardiovascular disease risk factors and estradiol.
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