ReviewBirth defects research2017
Cytomegalovirus infection in pregnancy.
Review in Birth defects research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
89 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The value of magnetic resonance imaging in congenital cytomegalovirus infection: a systematic review.Pediatric radiology · 2024Pooled it
- Cytomegalovirus Seropositivity and Suicidal Behavior: A Mini-Review.Medicina (Kaunas, Lithuania) · 2019Pooled it
- A Simplified Workflow for the Prediction of Putative Viral Reads Using NIPT Data.Prenatal diagnosis · 2026Article
- Article
- Seroprevalence and risk factors of cytomegalovirus infection in pregnant women in Lebanon: A retrospective study conducted at Hôtel-Dieu de France.IJID regions · 2026Article
- The Management of Congenital Cytomegalovirus Infection in an Era of Universal Newborn CMV Screening.Reviews in medical virology · 2026Review
- The Impact of Endocrine Disruptor Exposure During Pregnancy on Bacterial Complications and Viral Infections: A Narrative Review.Microorganisms · 2026Review
- A viral glycoprotein targets IgGEMBO molecular medicine · 2026Article
- Awareness and understanding of cytomegalovirus infection among polish pregnant women: A CASP-W cross-sectional study.Preventive medicine reports · 2026Article
- Optimizing delivery of an anti-cytomegalovirus inhibitory peptide using a cell-penetrating peptide.The Journal of general virology · 2026Article
- Associations Between Fetal Symptoms During Pregnancy and Neonatal Clinical Complications with Cytomegalovirus Infection.Children (Basel, Switzerland) · 2025Article
- When serology misleads: cross-reactivity in acute hepatitis.Archives of virology · 2025Review
- Human Cytomegalovirus Associated Neuropathies: A Comprehensive Review From Pathophysiology to Clinical and Therapeutic Considerations.Journal of the peripheral nervous system : JPNS · 2025Review
- A broad assessment of rotavirus vaccine safety in infants in Korea: Insights from a data-driven signal detection approach.Human vaccines & immunotherapeutics · 2025Article
- Clinical characteristics, pregnancy outcomes, and neonatal effects of cytomegalovirus infection in pregnant women in Liuzhou city, North central Guangxi of Southern China: a retrospective study from 2018 to 2024.BMC pregnancy and childbirth · 2025Article
- Review
- Congenital Cytomegalovirus Infection in Malaysia: A Scoping Review, Clinical Insights and Future Directions.The Malaysian journal of medical sciences : MJMS · 2025Review
- Use of antiviral medications during pregnancy and the likelihood of preeclampsia in a population-based register study.Scientific reports · 2025Article
- Cytomegalovirus Infection Screening in Pregnant Women from Northwest Romania: Results of a 15-Year Follow-Up Program.Microorganisms · 2025Article
- Lung NK cells are sufficient to control viral dissemination during respiratory MCMV infection.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Cytomegalovirus (CMV) is a DNA herpesvirus that is common worldwide. The two known main sources of primary CMV infection during pregnancy are through sexual activity and contact with young children. Primary infection occurs in approximately 1 to 4% of pregnancies, and is mostly asymptomatic in immunocompetent adults. However, primary infection may manifest as a mild mononucleosis or flu-like syndrome with persistent fever and fatigue. CMV can be transmitted from mother-to-child in utero, intrapartum, or during breastfeeding. Intrauterine transmission can lead to congenital CMV infection, a leading cause of permanent hearing and vision loss and neurological disability among children. Congenital CMV transmission rates are as high as 50% in women who acquire primary CMV infection during pregnancy, and less than 2% in women with nonprimary infection. There is no licensed CMV vaccine. Good hygiene practices and avoiding intimate contact with young children (e.g., kissing on the mouth and sharing utensils) have been suggested as an approach to prevent maternal primary CMV infection during pregnancy, but remains an unproven method of reducing the risk of congenital CMV infection. Approximately 1 in 10 infants who acquire CMV in utero will have clinical signs at birth, and an additional 10 to 15% will go on to develop late-onset sequelae. Antiviral treatment prenatally and postnatally has not proven effective at preventing congenital or postnatal CMV infection, and is not recommended for routine clinical care. However, antiviral treatment when initiated in the first month of life for symptomatic congenital CMV infection is recommended for improved neurodevelopmental and audiologic outcomes. Birth Defects Research 109:336-346, 2017. © 2017 Wiley Periodicals, Inc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.