Evidence map›Paper›PMID 28398643›Full record

ArticleCurrent protocols in neuroscience2017

Systems Genetic Analysis in GeneNetwork.org.

Clarissa C Parker, Price E Dickson, Vivek M Philip, Mary Thomas, Elissa J Chesler

Abstract read
In one paragraph

Article in Current protocols in neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Genome-wide screen identifies host loci that modulatebioRxiv : the preprint server for biology · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Systems genetics of sensation seeking.Genes, brain, and behavior · 2019
    Article
  14. Article
  15. Article
  16. Different Effect ofFrontiers in genetics · 2018
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Clarissa C ParkerDepartment of Psychology and Program in Neuroscience, Middlebury College, Middlebury, Vermont.
Price E DicksonCenter for Mammalian Genetics, The Jackson Laboratory, Bar Harbor, Maine.
Vivek M PhilipCenter for Computational Sciences, The Jackson Laboratory, Bar Harbor, Maine.
Mary ThomasDepartment of Psychology and Program in Neuroscience, Middlebury College, Middlebury, Vermont.
Elissa J CheslerCenter for Mammalian Genetics, The Jackson Laboratory, Bar Harbor, Maine.

Funding

Vermont INBRE Administrative Supplement 2024 AWD 118P20GM103449 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI CHRISTOPHER S FRANCKLYN · 2012 to 2026
$58.4M
Project 5: Circadian RhythmsP50DA039841 · NIDA · JACKSON LABORATORY · PI LAURA G REINHOLDT · 2016 to 2026
$26.2M
Discovery of Addiction-Related Genes with Advanced Mouse ResourcesR01DA037927 · NIDA · JACKSON LABORATORY · PI CHESLER, ELISSA J · 2015 to 2025
$8.1M
Data Structures, Algorithms and Tools for Ontological DiscoveryR01AA018776 · NIAAA · JACKSON LABORATORY · PI CHESLER, ELISSA J · 2010 to 2019
$3.9M
Genome-Wide Association for Affective Withdrawal in Outbred MiceR15DA041618 · NIDA · MIDDLEBURY COLLEGE · PI PARKER, CLARISSA C · 2016 to 2016
$320k
NIAAA NIH HHS R01 AA018776NIDA NIH HHS P50 DA039841NIDA NIH HHS R01 DA037927NIDA NIH HHS R15 DA041618NIGMS NIH HHS P20 GM103449
6 · The paper itself

Abstract

Genome-wide association studies (GWAS) have emerged as a powerful tool to identify alleles and molecular pathways that influence susceptibility to psychiatric disorders and other diseases. Forward genetics using mouse mapping populations allows for a complementary approach that provides rigorous genetic and environmental control. In this unit, we describe techniques and tools that reduce the technical burden traditionally associated with genetic mapping in mice and enhance their translational utility to human psychiatric disorders. We provide guidance on choosing the appropriate mapping population, discuss the importance of phenotype, and offer detailed instructions on using the Web-based resource GeneNetwork to aid neuroscientists in better understanding the mechanisms through which genes influence behavior. We believe that the continued development of mouse mapping populations, genetic tools, bioinformatics resources, and statistical methodologies should remain a parallel strategy by which to investigate the genetic and environmental underpinnings of psychiatric disorders and other diseases in humans. © 2017 by John Wiley & Sons, Inc.

Indexed as

AllelesAnimalsChromosome MappingDatabases, GeneticGenome-Wide Association StudyGenotypeHumansPhenotypeGeneNetworkquantitative trait locus mappingrecombinant inbred strainssystems genetics

Identifiers

PMID28398643
PMCPMC5548442

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.