ArticleSocial cognitive and affective neuroscience2017
Social anxiety disorder exhibit impaired networks involved in self and theory of mind processing.
Article in Social cognitive and affective neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- The multimodal neuroimaging signatures and gene expression profiles for adverse childhood experiences.BMC medicine · 2025Pooled it
- A systematic review and meta-analysis of resting-state fMRI in anxiety disorders: Need for data sharing to move the field forward.Journal of anxiety disorders · 2023Pooled it
- Resting-state neuroimaging in social anxiety disorder: a systematic review.Molecular psychiatry · 2022Pooled it
- Altered Theory of Mind Engagement and Neural Alignment in Social Anxiety During Movie Viewing.Biological psychiatry global open science · 2026Article
- Phenome-wide analysis of genetically imputed neuroimaging phenotypes reveals associations with psychiatric traits in a multi-ancestry cohort.medRxiv : the preprint server for health sciences · 2025Article
- A Heavy Feeling in the Stomach: Neural Correlates of Anxiety in Crohn's Disease.Neurogastroenterology and motility · 2025Article
- Neural circuit basis of pathological anxiety.Nature reviews. Neuroscience · 2025Review
- Dietary patterns, physical activity, and risk of urinary tract diseases: a two sample Mendelian randomization analysis.American journal of clinical and experimental immunology · 2025Article
- Social intelligence mediates the protective role of resting-state brain activity in the social cognition network against social anxiety.Psychoradiology · 2024Article
- Altered fractional amplitude of low-frequency fluctuations in the superior temporal gyrus: a resting-state fMRI study in anxious depression.BMC psychiatry · 2023Article
- A brain model of altered self-appraisal in social anxiety disorder.Translational psychiatry · 2023Article
- Enduring effect of abuse: Childhood maltreatment links to altered theory of mind network among adults.Human brain mapping · 2022Article
- Intrinsic functional connectivity in families genetically enriched for social anxiety disorder - an endophenotype study.EBioMedicine · 2021Article
- Dynamic changes of amplitude of low-frequency fluctuations in patients with generalized anxiety disorder.Human brain mapping · 2020Article
- Altered Default Mode Network and Salience Network Functional Connectivity in Patients with Generalized Anxiety Disorders: An ICA-Based Resting-State fMRI Study.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Imaging the socially-anxious brain: recent advances and future prospects.F1000Research · 2020Review
- Neural Correlates of Self-referential Processing and Their Clinical Implications in Social Anxiety Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2019Review
- Altered Brain Signal Variability in Patients With Generalized Anxiety Disorder.Frontiers in psychiatry · 2019Article
- Article
- Neuroimaging Predictors and Mechanisms of Treatment Response in Social Anxiety Disorder: an Overview of the Amygdala.Current psychiatry reports · 2018Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most previous studies regarding social anxiety disorder (SAD) have focused on the role of emotional dysfunction, while impairments in self- and theory of mind (ToM)-processing have relatively been neglected. This study utilised functional connectivity density (FCD), resting-state functional connectivity (RSFC) and discriminant analyses to investigate impairments in self- and ToM-related networks in patients with SAD. Patients with SAD exhibited decreased long-range FCD in the right rostral anterior cingulate cortex (rACC) and decreased short-range FCD in the right superior temporal gyrus (STG)-key nodes involved in self- and ToM-processing, respectively. Decreased RSFC of the right rACC and STG with widespread frontal, temporal, posteromedial, sensorimotor, and somatosensory, regions was also observed in patients with SAD. Altered RSFC between the right rACC and bilateral superior frontal gyrus, between the right rACC and right middle frontal gyrus, and within the right STG itself provided the greatest contribution to individual diagnoses of SAD, with an accuracy of 84.5%. These results suggest that a lack of cognitive inhibition on emotional self-referential processing as well as impairments in social information integration may play critical roles in the pathomechanism of SAD and highlight the importance of recognising such features in the diagnosis and treatment of SAD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.