ArticleNucleic acids research2017
Chiral metallohelices enantioselectively target hybrid human telomeric G-quadruplex DNA.
Article in Nucleic acids research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- Metallo-supramolecular complexes enantioselectively target monkeypox virus RNA G-quadruplex and bolster immune responses against MPXV.National science review · 2025Article
- Dicobalt(ii) helices kill colon cancer cellsChemical science · 2024Article
- DNA G-Quadruplexes as Targets for Natural Product Drug Discovery.Engineering (Beijing, China) · 2024Article
- Gaining Insights on the Interactions of a Class of Decorated (2-([2,2'-Bipyridin]-6-yl)phenyl)platinum Compounds with c-Myc Oncogene Promoter G-Quadruplex and Other DNA Structures.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Research Progress on G-Quadruplexes in Human Telomeres and Human Telomerase Reverse Transcriptase (hTERT) Promoter.Oxidative medicine and cellular longevity · 2022Review
- FeChemical science · 2021Article
- Metallohelices emulate the properties of short cationic α-helical peptides.Chemical science · 2021Review
- Cavity-Containing [FeFrontiers in chemistry · 2021Article
- Design and Applications of Water-Soluble Coordination Cages.Chemical reviews · 2020Article
- BMPQ-1 binds selectively to (3+1) hybrid topologies in human telomeric G-quadruplex multimers.Nucleic acids research · 2020Article
- Near-infrared-traceable DNA nano-hydrolase: specific eradication of telomeric G-overhang in vivo.Nucleic acids research · 2020Article
- Stabilization of human telomeric RNA G-quadruplex by the water-compatible optically pure and biologically-active metallohelices.Scientific reports · 2020Article
- Label-free single-molecule identification of telomere G-quadruplexes with a solid-state nanopore sensor.RSC advances · 2020Article
- Discovery of selective, antimetastatic and anti-cancer stem cell metallohelicesChemical science · 2019Article
- Importance of Chiral Recognition in Designing Metal-Free Ligands for G-Quadruplex DNA.Molecules (Basel, Switzerland) · 2019Article
- Recent Developments of Supramolecular Metal-based Structures for Applications in Cancer Therapy and Imaging.Theranostics · 2019Review
- Loop permutation affects the topology and stability of G-quadruplexes.Nucleic acids research · 2018Article
- Anticancer Activity and Cisplatin Binding Ability ofFrontiers in chemistry · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The design and synthesis of metal complexes that can specifically target DNA secondary structure has attracted considerable attention. Chiral metallosupramolecular complexes (e.g. helicates) in particular display unique DNA-binding behavior, however until recently few examples which are both water-compatible and enantiomerically pure have been reported. Herein we report that one metallohelix enantiomer Δ1a, available from a diastereoselective synthesis with no need for resolution, can enantioselectively stabilize human telomeric hybrid G-quadruplex and strongly inhibit telomerase activity with IC50 of 600 nM. In contrast, no such a preference is observed for the mirror image complex Λ1a. More intriguingly, neither of the two enantiomers binds specifically to human telomeric antiparallel G-quadruplex. To the best of our knowledge, this is the first example of one pair of enantiomers with contrasting selectivity for human telomeric hybrid G-quadruplex. Further studies show that Δ1a can discriminate human telomeric G-quadruplex from other telomeric G-quadruplexes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.