Evidence map›Paper›PMID 28398354›Full record

ArticleThe pharmacogenomics journal2018

Global genetic variation of select opiate metabolism genes in self-reported healthy individuals.

F R Wendt, G Pathak, A Sajantila, R Chakraborty, B Budowle

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in The pharmacogenomics journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Full-gene haplotypes refine CYP2D6 metabolizer phenotype inferences.International journal of legal medicine · 2018
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

F R WendtInstitute for Molecular Medicine, University of North Texas Health Science Center, Fort Worth, TX, USA.
G PathakInstitute for Molecular Medicine, University of North Texas Health Science Center, Fort Worth, TX, USA.
A SajantilaDepartment of Forensic Medicine, University of Helsinki, Helsinki, Finland.
R ChakrabortyInstitute for Molecular Medicine, University of North Texas Health Science Center, Fort Worth, TX, USA.
B BudowleInstitute for Molecular Medicine, University of North Texas Health Science Center, Fort Worth, TX, USA.
Institute for Molecular Medicine · USUniversity of Helsinki · FIUniversity of North Texas · USUniversity of North Texas Health Science Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CYP2D6 is a key pharmacogene encoding an enzyme impacting poor, intermediate, extensive and ultrarapid phase I metabolism of many marketed drugs. The pharmacogenetics of opiate drug metabolism is particularly interesting due to the relatively high incidence of addiction and overdose. Recently, trans-acting opiate metabolism and analgesic response enzymes (UGT2B7, ABCB1, OPRM1 and COMT) have been incorporated into pharmacogenetic studies to generate more comprehensive metabolic profiles of patients. With use of massively parallel sequencing, it is possible to identify additional polymorphisms that fine tune, or redefine, previous pharmacogenetic findings, which typically rely on targeted approaches. The 1000 Genomes Project data were analyzed to describe population genetic variation and statistics for these five genes in self-reported healthy individuals in five global super- and 26 sub-populations. Findings on the variation of these genes in various populations expand baseline understanding of pharmacogenetically relevant polymorphisms for future studies of affected cohorts.

Indexed as

Databases, GeneticSelf ReportAnalgesics, OpioidATP Binding Cassette Transporter, Subfamily BCatechol O-MethyltransferaseCytochrome P-450 CYP2D6GlucuronosyltransferaseHumansPharmacogenomic VariantsReceptors, Opioid, muABCB1 protein, humanAnalgesics, OpioidATP Binding Cassette Transporter, Subfamily BCatechol O-MethyltransferaseCOMT protein, humanCytochrome P-450 CYP2D6GlucuronosyltransferaseOPRM1 protein, humanReceptors, Opioid, muUGT2B7 protein, human

Identifiers

PMID28398354
OpenAlexW2606679475

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.