Evidence map›Paper›PMID 28398339›Full record

ReviewTranslational psychiatry2017

Animal models to improve our understanding and treatment of suicidal behavior.

T D Gould, P Georgiou, L A Brenner, L Brundin, A Can, P Courtet, Z R Donaldson, Y Dwivedi, S Guillaume, I I Gottesman and 10 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
10.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  6. Delineating impulsivity-based pathways to suicide deaths: A cluster analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 15 institutions in 5 countries.

T D GouldDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
P GeorgiouDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
L A BrennerDepartment of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
L BrundinCenter for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI, USA.
A CanDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
P CourtetDepartment of Emergency Psychiatry and Post Acute Care, CHU Montpellier, Montpellier, France.
Z R DonaldsonDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO, USA.
Y DwivediDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA.
S GuillaumeDepartment of Emergency Psychiatry and Post Acute Care, CHU Montpellier, Montpellier, France.
I I GottesmanDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
S KanekarDepartment of Psychiatry, University of Utah, Salt Lake City, UT, USA.
C A LowryRocky Mountain Mental Illness Research Education and Clinical Center, Denver, CO, USA.
P F RenshawRocky Mountain Mental Illness Research Education and Clinical Center, Denver, CO, USA.
D RujescuDepartment of Psychiatry, University of Halle-Wittenberg, Halle, Germany.
E G SmithEdith Nourse Rogers Memorial Veterans Hospital, Bedford, MA, USA.
G TureckiDepartment of Psychiatry, McGill University, Montreal, QC, Canada.
P ZanosDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
C A ZarateExperimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
P A ZunszainDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
T T PostolacheDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
University of Maryland, Baltimore · USMental Illness Research, Education and Clinical Centers · USUnited States Department of Veterans Affairs · USCentre Hospitalier Universitaire de Montpellier · FREdith Nourse Rogers Memorial Veterans Hospital · USKing's College London · GBMartin Luther University Halle-Wittenberg · DEMcGill University · CANational Institutes of Health · USUniversité de Montpellier · FRUniversity of Alabama at Birmingham · USUniversity of Colorado Boulder · USUniversity of Minnesota · USUniversity of Utah · USVan Andel Institute · US

Funding

Target validation of novel therapeutic agents in mood disordersZIAMH002927 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI ZARATE, CARLOS · 2010 to 2025
$37.1M
Plasma Exosomal MicroRNAs as Promising Novel Biomarkers for Suicidality and Treatment OutcomeR01MH107183 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DWIVEDI, YOGESH, SHELTON, RICHARD CHARLES · 2015 to 2019
$3.5M
Suicide Endophenotypes and Molecular Mechanisms of Lithium ActionR01MH091816 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI GOULD, TODD D · 2010 to 2014
$1.9M
MicroRNA Mapping in Major DepressionR01MH100616 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DWIVEDI, YOGESH · 2014 to 2019
$1.8M
Perturbed cell signaling network and suicide neurobiologyR01MH101890 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DWIVEDI, YOGESH · 2013 to 2017
$1.6M
Calcium Sensing Proteins in DepressionR01MH082802 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DWIVEDI, YOGESH · 2009 to 2013
$1.4M
Role of Kynurenine Pathway Metabolites in Perinatal Depression and SuicidalityR01MH104622 · NIMH · VAN ANDEL RESEARCH INSTITUTE · PI BRUNDIN, LENA CECILIA · 2014 to 2016
$1.2M
Variation in serotonin 1a receptor expression as a source of depression riskR00MH102352 · NIMH · UNIVERSITY OF COLORADO · PI DONALDSON, ZOE REBECCA · 2016 to 2018
$807k
Variation in serotonin 1a receptor expression as a source of depression riskK99MH102352 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI DONALDSON, ZOE REBECCA · 2014 to 2015
$264k
Improving Therapeutic Options for Hypoxia-related Depression with an Animal ModelI01BX002908 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI RENSHAW, PERRY FRANKLIN · 2016 to 2020
–
BLRD VA I01 BX002908NIMH NIH HHS K99 MH102352NIMH NIH HHS R00 MH102352NIMH NIH HHS R01 MH082802NIMH NIH HHS R01 MH091816NIMH NIH HHS R01 MH100616NIMH NIH HHS R01 MH101890NIMH NIH HHS R01 MH104622NIMH NIH HHS R01 MH107183
6 · The paper itself

Abstract

Worldwide, suicide is a leading cause of death. Although a sizable proportion of deaths by suicide may be preventable, it is well documented that despite major governmental and international investments in research, education and clinical practice suicide rates have not diminished and are even increasing among several at-risk populations. Although nonhuman animals do not engage in suicidal behavior amenable to translational studies, we argue that animal model systems are necessary to investigate candidate endophenotypes of suicidal behavior and the neurobiology underlying these endophenotypes. Animal models are similarly a critical resource to help delineate treatment targets and pharmacological means to improve our ability to manage the risk of suicide. In particular, certain pathophysiological pathways to suicidal behavior, including stress and hypothalamic-pituitary-adrenal axis dysfunction, neurotransmitter system abnormalities, endocrine and neuroimmune changes, aggression, impulsivity and decision-making deficits, as well as the role of critical interactions between genetic and epigenetic factors, development and environmental risk factors can be modeled in laboratory animals. We broadly describe human biological findings, as well as protective effects of medications such as lithium, clozapine, and ketamine associated with modifying risk of engaging in suicidal behavior that are readily translatable to animal models. Endophenotypes of suicidal behavior, studied in animal models, are further useful for moving observed associations with harmful environmental factors (for example, childhood adversity, mechanical trauma aeroallergens, pathogens, inflammation triggers) from association to causation, and developing preventative strategies. Further study in animals will contribute to a more informed, comprehensive, accelerated and ultimately impactful suicide research portfolio.

Indexed as

Disease Models, AnimalSuicidal IdeationSuicide PreventionAnimalsRisk FactorsSuicideSuicide, Attempted

Identifiers

PMID28398339
PMCPMC5416692
OpenAlexW2606077861

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.