ArticleMolecules (Basel, Switzerland)2017
Bergamot Essential Oil Attenuates Anxiety-Like Behaviour in Rats.
Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Essential Oils in Experimental Models of Neuropsychiatric Disorders: A Systematic Review.Current neuropharmacology · 2021Pooled it
- Promoting relaxation through essential oil-enhanced digital hypnotherapy: A randomized controlled trial.Psychological medicine · 2026Trial
- The effect of aromatherapy intervention with Bergamot and Grapefruit essential oils on premenstrual syndrome and menstrual symptoms: a randomized controlled trial.BMC complementary medicine and therapies · 2025Trial
- Fingered Citron Volatile Oil: Extraction Methods, Chemical Composition, Biological Activity, and Product Development.Current issues in molecular biology · 2026Review
- Exploring Linalool-Based Phytotherapy for Excitatory/Inhibitory Imbalance in Alzheimer's Disease: A Review of Lavender and Cannabis Therapeutic Effects on Sleep, Seizures, and Cognition.Phytotherapy research : PTR · 2026Review
- Using an aromatherapy intervention withInternational journal of nursing sciences · 2025Article
- A Neural Circuit For Bergamot Essential Oil-Induced Anxiolytic Effects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Citrus Essential Oils in Aromatherapy: Therapeutic Effects and Mechanisms.Antioxidants (Basel, Switzerland) · 2022Review
- Qualitative and quantitative analyses of chemical components of Citri Sarcodactylis Fructus from different origins based on UPLC-Q-Exactive Orbitrap-MS and GC-MS.Food science & nutrition · 2022Article
- Translational Value of the Transdermal Administration of Bergamot Essential Oil and of Its Fractions.Pharmaceutics · 2022Article
- Antispasmodic Effect of Bergamot Essential Oil on Rat Isolated Gut Tissues.Pharmaceutics · 2022Article
- In Vitro Assessment of the Cytotoxic and Antiproliferative Profile of Natural Preparations Containing Bergamot, Orange and Clove Essential Oils.Molecules (Basel, Switzerland) · 2022Article
- Preclinical Characterization of Antinociceptive Effect of Bergamot Essential Oil and of Its Fractions for Rational Translation in Complementary Therapy.Pharmaceutics · 2022Article
- The Effect of Copaiba Oil Odor on Anxiety Relief in Adults under Mental Workload: A Randomized Controlled Trial.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Inhalation AromatherapyFrontiers in pharmacology · 2022Review
- Dexmedetomidine Alleviates Intracerebral Hemorrhage-Induced Anxiety-Like Behaviors in Mice Through the Inhibition of TRPV4 Opening.Frontiers in pharmacology · 2022Article
- Modification of brain waves and sleep parameters by Citrus reticulata Blanco. cv. Sai-Nam-Phueng essential oil.Biomedical journal · 2021Article
- Neuroprotective Potential of Limonene and Limonene Containing Natural Products.Molecules (Basel, Switzerland) · 2021Review
- Anxiolytic Effect of Two Tobacco Essential Oils (Molecules (Basel, Switzerland) · 2021Article
- Nono-titanium dioxide exposure during the adolescent period induces neurotoxicities in rats: Ameliorative potential of bergamot essential oil.Brain and behavior · 2021Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preclinical studies have recently highlighted that bergamot essential oil (BEO) is endowed with remarkable neurobiolological effects. BEO can affect synaptic transmission, modulate electroencephalographic activity and it showed neuroprotective and analgesic properties. The phytocomplex, along with other essential oils, is also widely used in aromatherapy to minimize symptoms of stress-induced anxiety and mild mood disorders. However, only limited preclinical evidences are actually available. This study examined the anxiolytic/sedative-like effects of BEO using an open field task (OFT), an elevated plus-maze task (EPM), and a forced swimming task (FST) in rats. This study further compared behavioural effects of BEO to those of the benzodiazepine diazepam. Analysis of data suggests that BEO induces anxiolytic-like/relaxant effects in animal behavioural tasks not superimposable to those of the DZP. The present observations provide further insight to the pharmacological profile of BEO and support its rational use in aromatherapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.