ArticleNanomaterials (Basel, Switzerland)2017
Investigating the Origins of Toxic Response in TiO₂ Nanoparticle-Treated Cells.
Article in Nanomaterials (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 26 citations in OpenAlex.
- Toxicological Effects of Titanium Dioxide Nanoparticles on Human Menstrual Blood Mesenchymal Stem Cells.International journal of molecular sciences · 2025Article
- Evaluating the Use of TiOInternational journal of nanomedicine · 2022Article
- Titanium salts tested in reconstructed human skin with integrated MUTZ-3-derived Langerhans cells show an irritant rather than a sensitizing potential.Contact dermatitis · 2020Article
- Visible-Light Active Titanium Dioxide Nanomaterials with Bactericidal Properties.Nanomaterials (Basel, Switzerland) · 2020Review
- Preparation and Application of Bioshell Calcium Oxide (BiSCaO) Nanoparticle-Dispersions with Bactericidal Activity.Molecules (Basel, Switzerland) · 2019Article
- General review of titanium toxicity.International journal of implant dentistry · 2019Review
- Evaluation of immunoresponses and cytotoxicity from skin exposure to metallic nanoparticles.International journal of nanomedicine · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Titanium dioxide nanoparticles (TiO₂ NPs) are widely used in sunscreens, cosmetics and body implants, and this raises toxicity concerns. Although a large number of reports claim that they are safe to use, others claim that they induce reactive oxygen species formation and can be carcinogenic. In this study, the origins of toxic response to TiO₂ NPs were investigated by using Surface-enhanced Raman spectroscopy (SERS) which provides multidimensional information on the cellular dynamics at single cell level without any requirement for cell fixation. Three cell lines of vein (HUVEC), lung carcinoma (A549) and skin (L929) origin were tested for their toxic response upon exposure to 20, 40, 80 and 160 µg/mL anatase-TiO₂ NPs for 24 h. It was demonstrated that the level of toxic response is both cell line and dose-dependent. L929 fibroblasts were the most resistant cell line to oxidative stress whereas in HUVEC and A549, cell lines collagen and lipid deformation were observed, respectively.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.