ArticleNutrients2017
Genetic Risk Score of Nine Type 2 Diabetes Risk Variants that Interact with Erythrocyte Phospholipid Alpha-Linolenic Acid for Type 2 Diabetes in Chinese Hans: A Case-Control Study.
Article in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- The Effect of Plant-Derived Low-Ratio Linoleic Acid/α-Linolenic Acid on Markers of Glucose Controls: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2023Pooled it
- Effects of marine-derived and plant-derived omega-3 polyunsaturated fatty acids on erythrocyte fatty acid composition in type 2 diabetic patients.Lipids in health and disease · 2022Trial
- Seafood consumption and incident diabetes mellitus in middle-aged and elderly Chinese: results from the 4 C study.Nutrition journal · 2026Article
- Molecular Docking Integrated with Network Pharmacology Explores the Therapeutic Mechanism ofCurrent issues in molecular biology · 2023Article
- An early prediction model for gestational diabetes mellitus based on genetic variants and clinical characteristics in China.Diabetology & metabolic syndrome · 2022Article
- Genetic risk score to improve prediction and treatment in gestational diabetes mellitus.Frontiers in endocrinology · 2022Review
- Effect of dietary fat intake and genetic risk on glucose and insulin-related traits in Brazilian young adults.Journal of diabetes and metabolic disorders · 2021Article
- Lower Dietary Intake of Plant Protein Is Associated with Genetic Risk of Diabetes-Related Traits in Urban Asian Indian Adults.Nutrients · 2021Article
- Type 2 Diabetes-Associated Genetic Polymorphisms as Potential Disease Predictors.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Review
- The association of theInternational journal of clinical and experimental pathology · 2018Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Modulation of n-3 fatty acids on genetic susceptibility to type 2 diabetes (T2D) is still not clear. In a case-control study of 622 Chinese T2D patients and 293 healthy controls, a genetic risk score (GRS) was created based on nine T2D genetic variants. Logistic regression was used to examine the interaction of the GRS with erythrocyte phospholipid n-3 fatty acids for T2D risk. Every 1-unit (corresponding to 1 risk allele) increase in GRS was associated with 12% (Odds ratio (OR): 1.12; 95% confidence intervals (CI): 1.04-1.20) higher risk of T2D. Compared with the lowest quartile, participants had lower T2D risk in the 2nd (OR: 0.55; 95% CI: 0.36-0.84), 3rd (OR: 0.58; 95% CI: 0.38-0.88) and 4th (OR: 0.67; 95% CI: 0.44-1.03) quartile of alpha-linolenic acid (ALA) levels. Significant interaction (
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