ArticleJournal of biomechanical engineering2017
Cellular Microbiaxial Stretching to Measure a Single-Cell Strain Energy Density Function.
Article in Journal of biomechanical engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 34 citations in OpenAlex.
- Biomechanical research using advanced micro-nano devices: In-Vitro cell Characterization focus.Journal of advanced research · 2025Review
- A continuum model for tissues with moderate cell density.Computers in biology and medicine · 2025Article
- Biaxial length-tension relationship in single cardiac myocytes.Biophysical journal · 2025Article
- Pulling Frank-Starling into another dimension.Biophysical journal · 2025Article
- Adherent cells undergo rate softening mediated by actomyosin kinetics.Biophysical journal · 2025Article
- A Graphical Approach to Visualize and Interpret Biochemically Coupled Biomechanical Models.Journal of biomechanical engineering · 2024Article
- A computational bridge between traction force microscopy and tissue contraction.Journal of applied physics · 2023Article
- A structural bio-chemo-mechanical model for vascular smooth muscle cell traction force microscopy.Biomechanics and modeling in mechanobiology · 2023Article
- Orientation of neurites influences severity of mechanically induced tau pathology.Biophysical journal · 2021Article
- Investigation of Pathophysiological Aspects of Aortic Growth, Remodeling, and Failure Using a Discrete-Fiber Microstructural Model.Journal of biomechanical engineering · 2020Article
- Bimodal sensing of guidance cues in mechanically distinct microenvironments.Nature communications · 2018Article
- Architecture-Dependent Anisotropic Hysteresis in Smooth Muscle Cells.Biophysical journal · 2018Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The stress in a cell due to extracellular mechanical stimulus is determined by its mechanical properties, and the structural organization of many adherent cells suggests that their properties are anisotropic. This anisotropy may significantly influence the cells' mechanotransductive response to complex loads, and has important implications for development of accurate models of tissue biomechanics. Standard methods for measuring cellular mechanics report linear moduli that cannot capture large-deformation anisotropic properties, which in a continuum mechanics framework are best described by a strain energy density function (SED). In tissues, the SED is most robustly measured using biaxial testing. Here, we describe a cellular microbiaxial stretching (CμBS) method that modifies this tissue-scale approach to measure the anisotropic elastic behavior of individual vascular smooth muscle cells (VSMCs) with nativelike cytoarchitecture. Using CμBS, we reveal that VSMCs are highly anisotropic under large deformations. We then characterize a Holzapfel-Gasser-Ogden type SED for individual VSMCs and find that architecture-dependent properties of the cells can be robustly described using a formulation solely based on the organization of their actin cytoskeleton. These results suggest that cellular anisotropy should be considered when developing biomechanical models, and could play an important role in cellular mechano-adaptation.
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