ArticleScientific reports2017
Preventing the return of fear using reconsolidation updating and methylene blue is differentially dependent on extinction learning.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Neural substrates of propranolol-induced impairments in the reconsolidation of nicotine-associated memories in smokers.Translational psychiatry · 2021Trial
- Global remapping emerges as the mechanism for renewal of context-dependent behavior in a reinforcement learning model.Frontiers in computational neuroscience · 2024Article
- Enhancing Psychological Interventions for Post-Traumatic Stress Disorder (PTSD) Treatment with Memory Influencing Drugs.Current neuropharmacology · 2023Review
- The elegant complexity of fear in non-human animals.Emerging topics in life sciences · 2022Article
- Conjugates of Methylene Blue with Cycloalkaneindoles as New Multifunctional Agents for Potential Treatment of Neurodegenerative Disease.International journal of molecular sciences · 2022Article
- Testing the memory reconsolidation hypothesis in a fear extinction paradigm: The effects of ecological and arbitrary stimuli.Learning & behavior · 2022Article
- A proposed mechanism for the MDMA-mediated extinction of traumatic memories in PTSD patients treated with MDMA-assisted therapy.Frontiers in psychiatry · 2022Review
- Context-dependent extinction learning emerging from raw sensory inputs: a reinforcement learning approach.Scientific reports · 2021Article
- Sotalol Treatment may Interfere With Retrieval, Expression, and/or Reconsolidation Processes Thus Disrupting Traumatic Memories in a Post-Traumatic Stress Disorder Mice Model.Frontiers in pharmacology · 2021Article
- Methylene Blue Preserves Cytochrome Oxidase Activity and Prevents Neurodegeneration and Memory Impairment in Rats With Chronic Cerebral Hypoperfusion.Frontiers in cellular neuroscience · 2020Article
- The Secret of Fear Memory Attenuation: Facing Fears.Neuroscience bulletin · 2019Article
- Neurochemical and molecular mechanisms underlying the retrieval-extinction effect.Psychopharmacology · 2019Review
- Prefrontal-limbic Functional Connectivity during Acquisition and Extinction of Conditioned Fear.Neuroscience · 2018Article
- Data-driven criteria to assess fear remission and phenotypic variability of extinction in rats.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many factors account for how well individuals extinguish conditioned fears, such as genetic variability, learning capacity and conditions under which extinction training is administered. We predicted that memory-based interventions would be more effective to reduce the reinstatement of fear in subjects genetically predisposed to display more extinction learning. We tested this hypothesis in rats genetically selected for differences in fear extinction using two strategies: (1) attenuation of fear memory using post-retrieval extinction training, and (2) pharmacological enhancement of the extinction memory after extinction training by low-dose USP methylene blue (MB). Subjects selectively bred for divergent extinction phenotypes were fear conditioned to a tone stimulus and administered either standard extinction training or retrieval + extinction. Following extinction, subjects received injections of saline or MB. Both reconsolidation updating and MB administration showed beneficial effects in preventing fear reinstatement, but differed in the groups they targeted. Reconsolidation updating showed an overall effect in reducing fear reinstatement, whereas pharmacological memory enhancement using MB was an effective strategy, but only for individuals who were responsive to extinction.
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