ReviewLife (Basel, Switzerland)2017
Small and Random Peptides: An Unexplored Reservoir of Potentially Functional Primitive Organocatalysts. The Case of Seryl-Histidine.
Review in Life (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 51 citations in OpenAlex.
- Prebiotically Plausible Peptides can Self-assemble into β-rich Nanostructures.bioRxiv : the preprint server for biology · 2025Article
- Engineering and Exploiting Immobilized Peptide Organocatalysts for Modern Synthesis.Molecules (Basel, Switzerland) · 2025Review
- Wetware network-based AI: a chemical approach to embodied cognition for robotics and artificial intelligence.Frontiers in robotics and AI · 2025Article
- Peptides En Route from Prebiotic to Biotic Catalysis.Accounts of chemical research · 2024Article
- A Prebiotic Precursor to Life's Phosphate Transfer System with an ATP Analog and Histidyl Peptide Organocatalysts.Journal of the American Chemical Society · 2024Article
- A Simple Screening and Optimization Bioprocess for Long-Chain Peptide Catalysts Applied to Asymmetric Aldol Reaction.Molecules (Basel, Switzerland) · 2023Article
- Spontaneous Formation of Functional Structures in Messy Environments.Life (Basel, Switzerland) · 2022Article
- Development of fructose-1,6-bisphosphate aldolase enzyme peptide mimics as biocatalysts in direct asymmetric aldol reactions.RSC advances · 2021Article
- A Phage Display-Identified Short Peptide Capable of Hydrolyzing Calcium Pyrophosphate Crystals-The Etiological Factor of Chondrocalcinosis.Molecules (Basel, Switzerland) · 2021Article
- Fast bilayer-micelle fusion mediated by hydrophobic dipeptides.Biophysical journal · 2021Article
- Small Cyclic Peptide for Pyrophosphate Dependent Ligation in Prebiotic Environments.Life (Basel, Switzerland) · 2020Article
- A multifunctional surfactant catalyst inspired by hydrolases.Science advances · 2020Article
- Prebiotic condensation through wet-dry cycling regulated by deliquescence.Nature communications · 2019Article
- The Informational Substrate of Chemical Evolution: Implications for Abiogenesis.Life (Basel, Switzerland) · 2019Article
- Investigating Prebiotic Protocells for A Comprehensive Understanding of the Origins of Life: A Prebiotic Systems Chemistry Perspective.Life (Basel, Switzerland) · 2019Review
- Molecular Diversity Required for the Formation of Autocatalytic Sets.Life (Basel, Switzerland) · 2019Article
- Single-Frame, Multiple-Frame and Framing Motifs in Genes.Life (Basel, Switzerland) · 2019Article
- Systems protobiology: origin of life in lipid catalytic networks.Journal of the Royal Society, Interface · 2018Review
- Evolutionary convergence in the biosyntheses of the imidazole moieties of histidine and purines.PloS one · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Catalysis is an essential feature of living systems biochemistry, and probably, it played a key role in primordial times, helping to produce more complex molecules from simple ones. However, enzymes, the biocatalysts par excellence, were not available in such an ancient context, and so, instead, small molecule catalysis (organocatalysis) may have occurred. The best candidates for the role of primitive organocatalysts are amino acids and short random peptides, which are believed to have been available in an early period on Earth. In this review, we discuss the occurrence of primordial organocatalysts in the form of peptides, in particular commenting on reports about seryl-histidine dipeptide, which have recently been investigated. Starting from this specific case, we also mention a peptide fragment condensation scenario, as well as other potential roles of peptides in primordial times. The review actually aims to stimulate further investigation on an unexplored field of research, namely one that specifically looks at the catalytic activity of small random peptides with respect to reactions relevant to prebiotic chemistry and early chemical evolution.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.