Evidence map›Paper›PMID 28397397›Full record

ArticleJournal of thrombosis and haemostasis : JTH2017

The structural basis for the functional comparability of factor VIII and the long-acting variant recombinant factor VIII Fc fusion protein.

N C Leksa, P-L Chiu, G M Bou-Assaf, C Quan, Z Liu, A B Goodman, M G Chambers, S E Tsutakawa, M Hammel, R T Peters and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thrombosis and haemostasis : JTH, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  4. Article
  5. Review
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  8. Review
  9. [Advances of hemophilia A treatment].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

N C LeksaBiogen, Cambridge, MA, USA.
P-L ChiuDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA.
G M Bou-AssafBiogen, Cambridge, MA, USA.
C QuanBiogen, Cambridge, MA, USA.
Z LiuBiogen, Cambridge, MA, USA.
A B GoodmanBiogen, Cambridge, MA, USA.
M G ChambersDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA.
S E TsutakawaMolecular Biophysics & Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
M HammelMolecular Biophysics & Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
R T PetersBiogen, Cambridge, MA, USA.
T WalzBiogen, Cambridge, MA, USA.
J D KulmanBiogen, Cambridge, MA, USA.
Biogen (United States) · USLawrence Berkeley National Laboratory · USArizona State University · USCompass (United States) · USHarvard University · USRockefeller University · US

Funding

MINOS (Macromolecular Insights on Nucleic acids Optimized by Scattering)R01GM105404 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI TAINER, JOHN A. · 2012 to 2015
$2.1M
NIGMS NIH HHS R01 GM105404
6 · The paper itself

Abstract

Essentials Recombinant factor VIII (rFVIII) Fc fusion protein has a 1.5-fold longer half-life than rFVIII. Five orthogonal methods were used to characterize the structure of rFVIIIFc compared to rFVIII. The C-terminal Fc fusion does not perturb the structure of FVIII in rFVIIIFc. The FVIII and Fc components of rFVIIIFc are flexibly tethered and functionally independent. SUMMARY: Background Fusion of the human IgG

Indexed as

Crystallography, X-RayFactor VIIIHalf-LifeHEK293 CellsHemophilia AHemorrhageHumansImmunoglobulin Fc FragmentsKineticsMass SpectrometryMicroscopy, ElectronPeptide FragmentsProtein DomainsRecombinant Fusion ProteinsScattering, Small AngleSurface Plasmon ResonanceB-domain-deleted factor VIIIF8 protein, humanFactor VIIIfactor VIII-Fc fusion proteinImmunoglobulin Fc FragmentsPeptide FragmentsRecombinant Fusion ProteinsB-domain-deleted factor VIIIbleedingfactor VIIIhemophilia ArFVIIIFc protein

Identifiers

PMID28397397
PMCPMC5500164
OpenAlexW2606538420

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.