ArticleHuman brain mapping2017
Brain atrophy can introduce age-related differences in BOLD response.
Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Neural effects of oxytocin and mimicry in frontotemporal dementia: A randomized crossover study.Neurology · 2020Trial
- A Fully Automatic Technique for Precise Localization and Quantification of Amyloid-β PET Scans.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019Trial
- A Multimodal Dataset to Investigate Task-Evoked Negative BOLD Response and Neurodegeneration.Scientific data · 2026Article
- Age-related variations of the hemodynamic response function spatially resolved across human cerebral cortex.Frontiers in aging neuroscience · 2026Article
- Pulsatility analysis of the circle of Willis.Aging brain · 2024Article
- Evidence suggesting common mechanisms underlie contralateral and ipsilateral negative BOLD responses in the human visual cortex.NeuroImage · 2022Article
- Variation within the visually evoked neurovascular coupling response of the posterior cerebral artery is not influenced by age or sex.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Landmark-guided region-based spatial normalization for functional magnetic resonance imaging.Human brain mapping · 2022Article
- Hemodynamic response varies across tactile stimuli with different temporal structures.Human brain mapping · 2021Article
- On the Extraction and Analysis of Graphs From Resting-State fMRI to Support a Correct and Robust Diagnostic Tool for Alzheimer's Disease.Frontiers in neuroscience · 2018Article
- Task-Evoked Negative BOLD Response in the Default Mode Network Does Not Alter Its Functional Connectivity.Frontiers in computational neuroscience · 2018Article
- Advances in Studying Brain Morphology: The Benefits of Open-Access Data.Frontiers in human neuroscience · 2017Article
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5 authors.
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Abstract
Use of functional magnetic resonance imaging (fMRI) in studies of aging is often hampered by uncertainty about age-related differences in the amplitude and timing of the blood oxygenation level dependent (BOLD) response (i.e., hemodynamic impulse response function (HRF)). Such uncertainty introduces a significant challenge in the interpretation of the fMRI results. Even though this issue has been extensively investigated in the field of neuroimaging, there is currently no consensus about the existence and potential sources of age-related hemodynamic alterations. Using an event-related fMRI experiment with two robust and well-studied stimuli (visual and auditory), we detected a significant age-related difference in the amplitude of response to auditory stimulus. Accounting for brain atrophy by circumventing spatial normalization and processing the data in subjects' native space eliminated these observed differences. In addition, we simulated fMRI data using age differences in brain morphology while controlling HRF shape. Analyzing these simulated fMRI data using standard image processing resulted in differences in HRF amplitude, which were eliminated when the data were analyzed in subjects' native space. Our results indicate that age-related atrophy introduces inaccuracy in co-registration to standard space, which subsequently appears as attenuation in BOLD response amplitude. Our finding could explain some of the existing contradictory reports regarding age-related differences in the fMRI BOLD responses. Hum Brain Mapp 38:3402-3414, 2017. © 2017 Wiley Periodicals, Inc.
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