ArticleJournal of diabetes investigation2018
Continuous glucose monitoring reveals hypoglycemia risk in elderly patients with type 2 diabetes mellitus.
Article in Journal of diabetes investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Usability of Continuous Glucose Monitoring for Older Adults with Type 2 Diabetes: A Systematic Review.Diabetes technology & therapeutics · 2026Pooled it
- Management strategies in older adults with diabetes mellitus and polypharmacy; a narrative review.Hormones (Athens, Greece) · 2026Review
- Hypoglycaemia and its associations with diabetes and age-related factors in older home-dwelling people with diabetes.BMC geriatrics · 2025Observational
- Machine learning-based online prediction of nocturnal hypoglycemia in elderly patients with type 2 diabetes.Frontiers in endocrinology · 2025Article
- Expert Opinion on Current Trends in the Use of Insulin in the Management of People with Type 2 Diabetes from the South-Eastern European Region and Israel.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2024Review
- Mechanism of traditional Chinese medicine in elderly diabetes mellitus and a systematic review of its clinical application.Frontiers in pharmacology · 2024Review
- Dementia in Diabetes: The Role of Hypoglycemia.International journal of molecular sciences · 2023Review
- The association between hypoglycemia and glycemic variability in elderly patients with type 2 diabetes: a prospective observational study.Diabetology & metabolic syndrome · 2021Article
- Comparison of Visceral Fat Reduction by Ipragliflozin and Metformin in Elderly Type 2 Diabetes Patients: Sub-Analysis of a Randomized-Controlled Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2021Article
- Cognitive dysfunction during hypoglycemia in an elderly subject without diabetes.Diabetology international · 2020Article
- Review
- Recent advances in diabetes treatments and their perioperative implications.Current opinion in anaesthesiology · 2019 · on this mapReview
- A Retrospective Time Trend Study Of Diabetes Overtreatment In Geriatric Patients.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- A Retrospective Cohort Study of Patients with Type 2 Diabetes in China: Associations of Hypoglycemia with Health Care Resource Utilization and Associated Costs.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2018Article
- Continuous glucose monitoring reveals hypoglycemia risk in elderly patients with type 2 diabetes mellitus.Journal of diabetes investigation · 2018Article
- A systematic review on clinical implication of continuous glucose monitoring in diabetes management.Journal of pharmacy & bioallied sciencesReview
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AIMS/
introductionThe incidence of type 2 diabetes is higher in elderly patients, in whom this disease is associated with dementia, falling, stroke and death. We utilized a continuous glucose monitoring device to analyze the relationship between hypoglycemia and diabetes treatments to identify risk factors for hypoglycemia (defined as a blood glucose level <70 mg/dL). MATERIALS AND
methodsWe classified 170 patients aged ≥65 years with type 2 diabetes who were receiving steady-state medication (29 of whom were inpatients) into hypoglycemic and non-hypoglycemic groups, and compared their glycosylated hemoglobin levels, treatment types, continuous glucose monitoring data and other parameters. We carried out univariate analyses to identify variables associated with hypoglycemia risk, followed by multivariate analyses of drug class and other factors. The accuracy of the continuous glucose monitoring data was confirmed by calibration.
resultsHypoglycemia risk was higher in the patients using insulin (odds ratio [OR] 2.17, 95% confidence interval [CI] 1.16-4.08, P = 0.015), and lower in patients who were being treated with dipeptidyl peptidase-4 inhibitors (OR 0.47, 95% CI: 0.25-0.89, P = 0.019). Patients with lower variability in blood glucose had a significantly lower hypoglycemia risk (OR 0.87, 95% CI: 0.83-0.91, P < 0.0001), and those with a lower average blood glucose level had a significantly higher risk (OR 1.09, 95% CI: 1.06-1.12, P < 0.0001).
conclusionsIn patients aged ≥65 years with type 2 diabetes, higher glucose variability and lower average glucose levels indicate a greater hypoglycemia risk. It is therefore necessary to ensure comprehensive blood glucose control in such patients to prevent hypoglycemia.
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