Evidence map›Paper›PMID 28397153›Full record

ArticleMetabolic brain disease2017

MELDNa score is associated with psychopathology and reduced quality of life in cirrhotic patients with a liver transplant perspective.

Gabriele Cavaggioni, Edoardo Poli, Flaminia Ferri, Lucia Parlati, Valentina Monaco, Claudia Melcore, Barbara Lattanzi, Manuela Merli, Gianluca Mennini, Fabio Melandro and 2 more

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Article in Metabolic brain disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Gabriele CavaggioniDepartment of Neurology and Psychiatry, "Sapienza" University of Rome, Rome, Italy.
Edoardo PoliDepartment of Clinical Medicine, Division of Gastroenterology, "Sapienza" University of Rome, Viale dell' Università 37, 00185, Rome, Italy.
Flaminia FerriDepartment of Clinical Medicine, Division of Gastroenterology, "Sapienza" University of Rome, Viale dell' Università 37, 00185, Rome, Italy.
Lucia ParlatiDepartment of Clinical Medicine, Division of Gastroenterology, "Sapienza" University of Rome, Viale dell' Università 37, 00185, Rome, Italy.
Valentina MonacoDepartment of Neurology and Psychiatry, "Sapienza" University of Rome, Rome, Italy.
Claudia MelcoreDepartment of Neurology and Psychiatry, "Sapienza" University of Rome, Rome, Italy.
Barbara LattanziDepartment of Clinical Medicine, Division of Gastroenterology, "Sapienza" University of Rome, Viale dell' Università 37, 00185, Rome, Italy.
Manuela MerliDepartment of Clinical Medicine, Division of Gastroenterology, "Sapienza" University of Rome, Viale dell' Università 37, 00185, Rome, Italy.
Gianluca MenniniDepartment of General Surgery "Paride Stefanini" "Sapienza" University of Rome, Rome, Italy.
Fabio MelandroDepartment of General Surgery "Paride Stefanini" "Sapienza" University of Rome, Rome, Italy.
Massimo RossiDepartment of General Surgery "Paride Stefanini" "Sapienza" University of Rome, Rome, Italy.
Stefano Ginanni CorradiniDepartment of Clinical Medicine, Division of Gastroenterology, "Sapienza" University of Rome, Viale dell' Università 37, 00185, Rome, Italy. stefano.corradini@uniroma1.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psychopathological symptoms and reduced health related quality of life (HRQoL) are frequent in cirrhotics, but no data on their association with cirrhosis prognosis assessed by the MELDNa score are available. Prospective data on the long-term effect of deceased donor liver transplantation (LT) on psychopathological symptoms are needed. Before entering the LT waiting list, 44 consecutive LT cirrhotic candidates without a major psychiatric disorder underwent a psychopathological assessment, including Symptom Checklist-90-revised (SCL-90-R) and Defense Style Questionnaire (DSQ). HRQoL was measured by Short Form 36 Health Survey (SF-36). Abnormal performance at each questionnaire was defined by using 44 age, gender, BMI and education-matched healthy subjects. Separate binary logistic regression models were used to test the association of the Child-Pugh, MELD and MELDNa scores with abnormal performance at each questionnaire. Fourteen patients repeated the battery tests 3 years after LT. Before LT, increasing MELDNa was the only prognostic score independently associated with an abnormal SCL-90-R global psychopathological score index (OR: 1.207; 95% CI: 1.026-1.420; P = 0.02) and the best independent predictor of reduced HRQoL. After LT, compared to status prior to LT, performance at SF-36 general health perception scale ameliorated (P = 0.02), performance at SCL-90-R somatization scale (P = 0.001) and global psychopathological score index (P < 0.001) worsened and the negative correlation between the psychopathological global score index and HRQoL disappeared. The severity of cirrhosis in LT candidates should be monitored by the MELDNa score to better establish the right psychological counselling. Psychopathology, and in particular somatization, worsens after LT and should be carefully investigated.

Indexed as

Severity of Illness IndexSurveys and QuestionnairesEnd Stage Liver DiseaseFemaleHumansLiver CirrhosisLiver TransplantationMaleMiddle AgedProspective StudiesQuality of LifeCirrhosisLiver transplantationMELDNaPsychopathologyQuality of life

Identifiers

PMID28397153

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.