ReviewCurrent gastroenterology reports2017
Antidiarrheal Drug Therapy.
Review in Current gastroenterology reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Article
- Investigations of the voltage-gated CaFrontiers in pharmacology · 2026Article
- Evaluation of the Antidiarrheal Activity of 80% Methanolic Extract and Solvent Fractions of Calpurnia aurea (Ait.) Benth. (Fabaceae) Roots in Swiss Albino Mice.BioMed research international · 2026Article
- Racecadotril Versus Loperamide for Acute Diarrhea of Infectious Origin in Adults: A Systematic Review and Meta-Analysis.Health science reports · 2025Review
- Crohn's disease, irritable bowel syndrome, and chronic fatigue: the importance of communication and symptom management-a case report.Journal of medical case reports · 2025Article
- Article
- Lymphocytic colitis associated with entacapone.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2022Article
- Dual Inhibition of Phosphodiesterase and CaPlants (Basel, Switzerland) · 2022Article
- [Definition and treatment of superior mesenteric artery revascularization and dissection-associated diarrhea (SMARD syndrome) in Germany].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2022Review
- Effects of α2-adrenoceptor stimulation on luminal alkalinisation and net fluid flux in rat duodenum.PloS one · 2022Article
- Association Between Antidiarrheal Drug Prescription and Return Visits Among Adult Patients With Acute Diarrhea.Cureus · 2021Article
- The Role of Purported Mucoprotectants in Dealing with Irritable Bowel Syndrome, Functional Diarrhea, and Other Chronic Diarrheal Disorders in Adults.Advances in therapy · 2021Review
- Understanding the Ethnobotany, Chemistry, Pharmacology, and Distribution of GenusPlants (Basel, Switzerland) · 2021Review
- Antifungal activity and antidiarrheal activityWorld journal of gastroenterology · 2020Article
- Antidiarrheal Effect of Sechang-Zhixie-San on Acute Diarrhea Mice and Network Pharmacology Deciphering Its Characteristics and Potential Mechanisms.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Toxicological and Pharmacological Activities ofFrontiers in pharmacology · 2020Article
- Chronic Diarrhea Evaluation in the Elderly: IBS or Something Else?Current gastroenterology reports · 2019Review
- The Effects of Fecal Donors with Different Feeding Patterns on Diarrhea in a Patient Undergoing Hematopoietic Stem Cell Transplantation.Case reports in hematology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAcute diarrhea often runs a self-limited course and little by way of treatment is needed except for oral rehydration therapy. Chronic diarrhea poses a longer-term problem. If not treatable with specific therapy aimed at the underlying pathophysiology, chronic diarrhea often needs long-term symptomatic therapy. PURPOSE OF REVIEW: This paper aims to examine the options for symptomatic, nonspecific treatment of diarrhea. RECENT
findingsThe most frequently used therapies are opiate antidiarrheal drugs. These drugs are effective for a wide variety of diarrheal conditions and generally can be used safely if monitored closely. They work by slowing motility and allowing more time for absorption. They vary in potency and in addictive liability. In recent years, a variety of other drugs have been developed, which provide more targeted therapy that can mitigate diarrhea in specific situations. These drugs work on other regulatory pathways in the gut or on mucosal absorptive mechanisms. There is evidence for efficacy for both traditional and newer agents used for the symptomatic management of diarrhea. Opiates are used most often for this indication. Other agents may benefit individuals, but further research is needed to establish indications and best practices.
Indexed as
Identifiers
28397130What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.