ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2017
The burden and epidemiology of community-acquired central nervous system infections: a multinational study.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
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Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The added value of metagenomic next-generation sequencing in central nervous system infections: a systematic review of case reports.Infection · 2025Pooled it
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- Prognostic predictors in HIV-negative neurosyphilis: a retrospective cohort study with prospective follow-up.BMC infectious diseases · 2026Article
- The Clinical Utility of Serum Biomarkers in the Differentiation and Prognostic Assessment of Viral Meningitis.Pathogens (Basel, Switzerland) · 2026Article
- A Case Report of Meningitis with Possible Coinfection byCase reports in critical care · 2026Article
- Managing penicillin resistant pneumococcal meningitis: an international id-iri study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
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- The Neuroinfectious diseases profile in a specialist neurology centre in South Africa.eNeurologicalSci · 2025Article
- CEST MRI in the Management/Diagnosis of Neuroinfectious Diseases.International journal of molecular sciences · 2025Review
- Clinicodemographic and Radiological Features of Infective Ring-Enhancing Brain Lesions: A 4-Year Retrospective Study at a Tertiary Referral Center.Open forum infectious diseases · 2025Article
- Symptomatic neurosyphilis in HIV-negative patients: a retrospective cohort study.Frontiers in public health · 2025Article
- Understanding the mechanisms ofTissue barriers · 2025Review
- Double trouble: The intersection of neurobrucellosis and systemic lupus erythematosus in a 24-year-old female.eNeurologicalSci · 2024Article
- Radiomics features for the discrimination of tuberculomas from high grade gliomas and metastasis: a multimodal study.Neuroradiology · 2024Article
- The challenge of etiologic diagnosis of subacute and chronic meningitis: an analysis of 183 patients.Epidemiology and infection · 2024Article
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- Effects of climatic and environmental factors on mosquito population inferred from West Nile virus surveillance in Greece.Scientific reports · 2023Article
- The MetaGens algorithm for metagenomic database lossy compression and subject alignment.Database : the journal of biological databases and curation · 2023Article
- [Transmission routes of neuropathogenic pathogens-Possible mechanisms of neuroinvasion].Der Nervenarzt · 2023Review
- Severe community-acquired Streptococcus pneumoniae bacterial meningitis: clinical and prognostic picture from the intensive care unit.Critical care (London, England) · 2023Observational
Corrections and comments
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Authors and funding
75 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Risk assessment of central nervous system (CNS) infection patients is of key importance in predicting likely pathogens. However, data are lacking on the epidemiology globally. We performed a multicenter study to understand the burden of community-acquired CNS (CA-CNS) infections between 2012 and 2014. A total of 2583 patients with CA-CNS infections were included from 37 referral centers in 20 countries. Of these, 477 (18.5%) patients survived with sequelae and 227 (8.8%) died, and 1879 (72.7%) patients were discharged with complete cure. The most frequent infecting pathogens in this study were Streptococcus pneumoniae (n = 206, 8%) and Mycobacterium tuberculosis (n = 152, 5.9%). Varicella zoster virus and Listeria were other common pathogens in the elderly. Although staphylococci and Listeria resulted in frequent infections in immunocompromised patients, cryptococci were leading pathogens in human immunodeficiency virus (HIV)-positive individuals. Among the patients with any proven etiology, 96 (8.9%) patients presented with clinical features of a chronic CNS disease. Neurosyphilis, neurobrucellosis, neuroborreliosis, and CNS tuberculosis had a predilection to present chronic courses. Listeria monocytogenes, Staphylococcus aureus, M. tuberculosis, and S. pneumoniae were the most fatal forms, while sequelae were significantly higher for herpes simplex virus type 1 (p < 0.05 for all). Tackling the high burden of CNS infections globally can only be achieved with effective pneumococcal immunization and strategies to eliminate tuberculosis, and more must be done to improve diagnostic capacity.
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