ReviewJournal of neurology2017
Gait ataxia in humans: vestibular and cerebellar control of dynamic stability.
Review in Journal of neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Non-invasive neuromodulation in reducing the risk of falls and fear of falling in community-dwelling older adults: systematic review.Frontiers in aging neuroscience · 2023Pooled it
- Disentangling Cerebellar and Parietal Contributions to Gait and Body Schema: A Repetitive Transcranial Magnetic Stimulation Study.Cerebellum (London, England) · 2024Trial
- Volumetric Examination of Cerebellum by Automatic Segmentation Method in Individuals with Ankylosing Spondylitis.Cerebellum (London, England) · 2026Article
- Walking as a Window to the Brain: Redefining Gait in Neurology.Medical sciences (Basel, Switzerland) · 2026Review
- Feasibility and Short-term Functional Outcomes of Early Gait Training within 14 days after Thoracic Myelopathy Surgery: A Retrospective Case Series.Progress in rehabilitation medicine · 2026Article
- Feasibility of Smartphone-Based Markerless Motion Capture for Quantitative Gait Assessment in Pediatric Guillain-Barré Syndrome: A Two-Case Proof-of-Concept Study.Bioengineering (Basel, Switzerland) · 2025Article
- Efficacy and Safety Analysis of Repetitive Transcranial Magnetic Stimulation in Patients with Persistent Postural Perceptual Dizziness: A Single-Center, Single-Blind, Randomized Placebo-Controlled Trial.Neurology and therapy · 2025Article
- Clinical Whole-Body Gait Characterization Using a Single RGB-D Sensor.Sensors (Basel, Switzerland) · 2025Article
- Gait impairments in patients with bilateral vestibulopathy and chronic unilateral vestibulopathy.Frontiers in neurology · 2025Article
- Mobile Spatiotemporal Gait Segmentation Using an Ear-Worn Motion Sensor and Deep Learning.Sensors (Basel, Switzerland) · 2024Article
- Vestibular perceptual learning improves self-motion perception, posture, and gait in older adults.Communications biology · 2024Article
- Advanced progress of vestibular compensation in vestibular neural networks.CNS neuroscience & therapeutics · 2024Review
- Exploring the Therapeutic Effects and Mechanisms of Transcranial Alternating Current Stimulation on Improving Walking Ability in Stroke Patients via Modulating Cerebellar Gamma Frequency Band-a Narrative Review.Cerebellum (London, England) · 2024Review
- Mechanisms underlying treatment effects of vestibular noise stimulation on postural instability in patients with bilateral vestibulopathy.Journal of neurology · 2024Article
- Morphological changes in the cerebellum during aging: evidence from convolutional neural networks and shape analysis.Frontiers in aging neuroscience · 2024Article
- Examination of the Development and Asymmetry of the Cerebellum and Its Lobules in Individuals Aged 1-18 Years: A Retrospective MRI Study.Brain topography · 2023Article
- Injury of the Vestibulocerebellar Tract and Signs of Ataxia in Patients with Cerebellar Stroke.Journal of clinical medicine · 2023Article
- Repetitive Low-Intensity Vestibular Noise Stimulation Partly Reverses Behavioral and Brain Activity Changes following Bilateral Vestibular Loss in Rats.Biomolecules · 2023Article
- Therapeutic Strategies for Spinocerebellar Ataxia Type 1.Biomolecules · 2023Review
- Multimodal Mobility Assessment Predicts Fall Frequency and Severity in Cerebellar Ataxia.Cerebellum (London, England) · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During human locomotion, vestibular feedback control is fundamental for maintaining dynamic stability and adapting the gait pattern to external circumstances. Within the supraspinal locomotor network, the cerebellum represents the key site for the integration of vestibular feedback information. The cerebellum is further important for the fine-tuning and coordination of limb movements during walking. The aim of this review article is to highlight the shared structural and functional sensorimotor principles in vestibular and cerebellar locomotion control. Vestibular feedback for the maintenance of dynamic stability is integrated into the locomotor pattern via midline, caudal cerebellar structures (vermis, flocculonodular lobe). Hemispheric regions of the cerebellum facilitate feed-forward control of multi-joint coordination and higher locomotor functions. Characteristic features of the gait disorder in patients with vestibular deficits or cerebellar ataxia are increased levels of spatiotemporal gait variability in the fore-aft and the medio-lateral gait dimension. In the fore-aft dimension, pathologic increases of gait fluctuations critically depend on the locomotion speed and predominantly manifest during slow walking velocities. This feature is associated with an increased risk of falls in both patients with vestibular hypofunction as well as patients with cerebellar ataxia. Pharmacological approaches for the treatment of vestibular or cerebellar gait ataxia are currently not available. However, new promising options are currently tested in randomized, controlled trials (fampridine/FACEG; acetyl-DL-leucine/ALCAT).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.