ArticleEuropean radiology2017
Diffusion-weighted (DW) MRI in lung cancers: ADC test-retest repeatability.
Article in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Twenty Years On: RECIST as a Biomarker of Response in Solid Tumours an EORTC Imaging Group - ESOI Joint Paper.Frontiers in oncology · 2021Pooled it
- Differentiating the lung lesions using Intravoxel incoherent motion diffusion-weighted imaging: a meta-analysis.BMC cancer · 2020Pooled it
- Radiomics signature based on robust features derived from diffusion data for differentiation between benign and malignant solitary pulmonary lesions.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Trial
- Evaluating a Cellular Microstructure Model Within Apoptotic Cell Death via Diffusion Magnetic Resonance and Long Diffusion Times.NMR in biomedicine · 2025Article
- A multicenter study of cervical cancer using quantitative diffusion-weighted imaging.Acta radiologica (Stockholm, Sweden : 1987) · 2024Article
- A Prospective Observational Study of Diagnostic Reliability of Semiquantitative and Quantitative High b-Value Diffusion-Weighted MRI in Distinguishing between Benign and Malignant Lung Lesions at 3 Tesla.The Indian journal of radiology & imaging · 2024Article
- The role of clinical imaging in oncology drug development: progress and new challenges.The British journal of radiology · 2023Review
- Stability and repeatability of diffusion-weighted imaging (DWI) of normal pancreas on 5.0 Tesla magnetic resonance imaging (MRI).Scientific reports · 2023Article
- Repeatability and test-retest reproducibility of mean apparent diffusion coefficient measurements of focal and diffuse disease in relapsed multiple myeloma at 3T whole body diffusion-weighted MRI (WB-DW-MRI).The British journal of radiology · 2022Article
- Challenges in ensuring the generalizability of image quantitation methods for MRI.Medical physics · 2022Review
- Native T1-mapping and diffusion-weighted imaging (DWI) can be used to identify lung cancer pathological types and their correlation with Ki-67 expression.Journal of thoracic disease · 2022Article
- Magnetic Fields and Cancer: Epidemiology, Cellular Biology, and Theranostics.International journal of molecular sciences · 2022Review
- Statistical considerations for repeatability and reproducibility of quantitative imaging biomarkers.BJR open · 2022Review
- Radiomics of diffusion-weighted MRI compared to conventional measurement of apparent diffusion-coefficient for differentiation between benign and malignant soft tissue tumors.Scientific reports · 2021Article
- Article
- The Benefit of Apparent Diffusion Coefficient in Evaluating the Invasiveness of Hepatocellular Carcinoma.Frontiers in oncology · 2021Article
- A review of the role of MRI in diagnosis and treatment of early stage lung cancer.Clinical and translational radiation oncology · 2020Review
- The value of diffusion-weighted imaging based on monoexponential and biexponential models for the diagnosis of benign and malignant lung nodules and masses.The British journal of radiology · 2020Article
- Quantitative imaging biomarkers alliance (QIBA) recommendations for improved precision of DWI and DCE-MRI derived biomarkers in multicenter oncology trials.Journal of magnetic resonance imaging : JMRI · 2019Review
- Very Early Response Evaluation by PET/MR in Patients with Lung Cancer-Timing and Feasibility.Diagnostics (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 4 countries.
Funding
Abstract
purposeTo determine the test-retest repeatability of Apparent Diffusion Coefficient (ADC) measurements across institutions and MRI vendors, plus investigate the effect of post-processing methodology on measurement precision.
methodsThirty malignant lung lesions >2 cm in size (23 patients) were scanned on two occasions, using echo-planar-Diffusion-Weighted (DW)-MRI to derive whole-tumour ADC (b = 100, 500 and 800smm
resultsWhole-tumour ADC values ranged from 0.66-1.94x10
conclusionA free-breathing DW-MRI protocol for imaging malignant lung tumours achieved satisfactory within-patient repeatability and was robust to changes in post-processing software, justifying its use in multi-centre trials. For response evaluation in individual patients, a change in ADC >21.9% will reflect treatment-related change. KEY POINTS: • In lung cancer, free-breathing DWI-MRI produces acceptable images with evaluable ADC measurement. • ADC repeatability coefficient-of-variation is 7.1% for lung tumours >2 cm. • ADC repeatability coefficient-of-variation is 3.9% for lung tumours >3 cm. • ADC measurement precision is unaffected by the post-processing software used. • In multicentre trials, 22% increase in ADC indicates positive treatment response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.