Evidence map›Paper›PMID 28396962›Full record

ReviewSkeletal radiology2017

Elevated β-hCG associated with aggressive Osteoblastoma.

Carol D Morris, Meera R Hameed, Narasimhan P Agaram, Sinchun Hwang

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Skeletal radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Carol D MorrisDivision of Orthopaedic Oncology, Department of Orthopaedic Surgery, The Johns Hopkins Hospital, 601 North Caroline Street, Baltimore, MD, 21287, USA. cmorri61@jhmi.edu.
Meera R HameedDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Narasimhan P AgaramDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Sinchun HwangDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Memorial Sloan Kettering Cancer Center · USJohns Hopkins Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a unique case of an aggressive scapular osteoblastoma that produced β-hCG as a paraneoplastic manifestation in a 20-year-old woman. Serum β-hCG was found to be elevated during presurgical workup and consequently delayed surgical resection of the increasingly painful tumor because of suspected pregnancy. The paraneoplastic production of β-hCG was later proven by positive immunohistochemical stain of β-hCG in a curettage specimen and normalization of β-hCG levels after surgical resection of the aggressive osteoblastoma. Production of beta-human chorionic gonadotropin (β-hCG) has been reported in several carcinomas and sarcomas but, to our knowledge, it has not been reported in osteoblastoma in the English-language literature.

Indexed as

ScapulaBiomarkers, TumorChorionic Gonadotropin, beta Subunit, HumanContrast MediaDiagnosis, DifferentialFemaleHumansImmunohistochemistryMagnetic Resonance ImagingOsteoblastomaTomography, X-Ray ComputedWhole Body ImagingYoung AdultBiomarkers, TumorChorionic Gonadotropin, beta Subunit, HumanContrast MediaBeta-human chorionic gonadotropinOsteoblastoma, paraneoplasticβ-hCG

Identifiers

PMID28396962
OpenAlexW2606701257

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.