Evidence map›Paper›PMID 28396927›Full record

SynthesisInternational orthopaedics2017

A systematic review and meta-analysis of platelet-rich plasma versus corticosteroid injections for plantar fasciopathy.

Prashant Singh, Suroosh Madanipour, Jagmeet S Bhamra, Ian Gill

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in International orthopaedics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05240872 (Is There Any Advantage of PRP Over Autologous Blood Injection in the Treatment of Chronic Plantar Fasciitis? A Prospective Randomized Double Blinded Study), which is not on this map. Cited by 31 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05240872 phase3completednot on this mapstarted 2020, after this paper: background citation

Is There Any Advantage of PRP Over Autologous Blood Injection in the Treatment of Chronic Plantar Fasciitis? A Prospective Randomized Double Blinded Study

TypeinterventionalSponsorIstanbul Training and Research HospitalRan2020 to 2022Enrolled60ConditionsPlantar FascitisArmsPRP injection, ABI injection
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  18. The 2020 NBA Orthobiologics Consensus Statement.Orthopaedic journal of sports medicine · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Prashant SinghDepartment of Trauma and Orthopaedic Surgery, Kingston Hospital NHS Foundation Trust, Galsworthy Road, Kingston upon Thames, KT2 7QB, UK. Prashant001@aol.com.ORCID 0000-0003-2480-3425
Suroosh MadanipourRoyal Free London NHS Trust, London, UK.
Jagmeet S BhamraLewisham and Greenwich NHS Trust, London, UK.
Ian GillDepartment of Trauma and Orthopaedic Surgery, Kingston Hospital NHS Foundation Trust, Galsworthy Road, Kingston upon Thames, KT2 7QB, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine whether platelet-rich plasma (PRP) injections are associated with improved pain and function scores when compared with corticosteroid injections for plantar fasciopathy.

methodsA systematic review of published literature was performed for studies comparing PRP injections and corticosteroid injections for plantar fasciopathy. Studies were assessed using the Cochrane Risk of Bias Tool and the Newcastle Ottawa Scale (NOS). The primary endpoint was pain and function score at three and six month follow-up. Sensitivity analysis was performed for high quality studies and randomised studies.

resultsTen studies totalling 517 patients were included. Seven studies were randomised. All studies included patients who had failed conservative measures and excluded patients with systemic illness and other causes of foot pain. Studies reported outcomes using the visual analogue score (VAS) and American Orthopaedic Foot and Ankle Score (AOFAS). At 3-month follow-up, PRP injections were associated with improved VAS scores (standard mean difference [SMD], -0.66; 95% CI, -1.3 to -0.02; p = 0.04) and AOFAS scores (SMD, 1.87; 95% CI, 0.16-3.58; p = 0.03). At 6-month follow-up, there was no difference in VAS score (SMD, -0.66; 95% CI, -1.65 to 0.3; p = 0.17) or AOFAS scores (SMD, 1.69; 95% CI, -1.06 to 4.45; p = 0.23). No studies reported adverse event rates or cost analysis. There was no difference in pain or function score at one, six- or 12-month follow-up. Sensitivity analyses of high-quality studies showed no differences between the PRP and steroid group at any of the follow-up points.

conclusionsPRP injections are associated with improved pain and function scores at three month follow-up when compared with corticosteroid injections. Information regarding relative adverse event rates and cost implications is lacking. Further, large-scale, high-quality, randomised controlled trials with blinding of outcome assessment and longer follow-up are required.

Indexed as

AdultFasciitis, PlantarGlucocorticoidsHumansMiddle AgedPainPain MeasurementPlatelet-Rich PlasmaGlucocorticoidsCorticosteroidsMeta-analysisPlantar fasciopathyPlatelet rich plasma

Identifiers

PMID28396927

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.