Evidence map›Paper›PMID 28396906›Full record

ArticleSocial psychiatry and psychiatric epidemiology2017

The Lausanne-Geneva cohort study of offspring of parents with mood disorders: methodology, findings, current sample characteristics, and perspectives.

Caroline L Vandeleur, Marie-Pierre F Strippoli, Enrique Castelao, Mehdi Gholam-Rezaee, François Ferrero, Pierre Marquet, Jean-Michel Aubry, Martin Preisig

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Social psychiatry and psychiatric epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Caroline L VandeleurDepartment of Psychiatry, University Hospital of Lausanne, Site de Cery, Prilly, 1008, Lausanne, Switzerland. Caroline.Vandeleur@chuv.ch.
Marie-Pierre F StrippoliDepartment of Psychiatry, University Hospital of Lausanne, Site de Cery, Prilly, 1008, Lausanne, Switzerland.
Enrique CastelaoDepartment of Psychiatry, University Hospital of Lausanne, Site de Cery, Prilly, 1008, Lausanne, Switzerland.
Mehdi Gholam-RezaeeDepartment of Psychiatry, University Hospital of Lausanne, Site de Cery, Prilly, 1008, Lausanne, Switzerland.
François FerreroDepartment of Mental Health and Psychiatry, University Hospital of Geneva, Geneva, Switzerland.
Pierre MarquetDepartment of Psychiatry, University Hospital of Lausanne, Site de Cery, Prilly, 1008, Lausanne, Switzerland.
Jean-Michel AubryDepartment of Mental Health and Psychiatry, University Hospital of Geneva, Geneva, Switzerland.
Martin PreisigDepartment of Psychiatry, University Hospital of Lausanne, Site de Cery, Prilly, 1008, Lausanne, Switzerland.
University Hospital of Lausanne · CHHôpital de Cery · CHUniversity Hospital of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeStudies focusing on the offspring of affected parents utilize the well-established familial aggregation of mood disorders as a powerful tool for the identification of risk factors, early clinical manifestations, and prodromes of mood disorders in these offspring. The major goals of the Lausanne-Geneva mood cohort study are to: (1) assess the familial aggregation of bipolar and unipolar mood disorders; (2) prospectively identify risk factors for mood disorders as well as their early signs and prodromes; (3) identify their endophenotypes including cognitive features, alterations in brain structure, HPA-axis dysregulation, and abnormalities of the circadian rhythm of activity.

methodsProbands with bipolar disorders, major depressive disorder, and controls with at least one child aged from 4 to 17.9 years at study intake, their offspring, as well as their spouses are invited to take part in follow-up assessments at predetermined ages of the offspring. Direct semi-structured diagnostic interviews have been used for all participants. Probands, spouses, and adult offspring also undergo neurocognitive testing, anthropomorphic measures and biochemical exams, structural Magnetic Resonance Imaging, as well as objective assessments of physical activity using accelerometers in combination with ecological momentary assessments.

resultsCurrently, our study has up to seven follow-up assessments extending over a period of 20 years. There are 214 probands and 389 offspring with one direct interview before age 18 as well as a second assessment over follow-up. Data on 236 co-parents are also available from whom 55% have been directly interviewed. First publications support the specificity of the familial aggregation of BPD and the strong influence of an early onset of the parental BPD, which amplifies the risk of developing this disorder in offspring.

conclusionsInformation from clinical, biological, cognitive, and behavioral measures, based on contemporary knowledge, should further enhance our understanding of mood disorder psychopathology, its consequences, and underlying mechanisms.

Indexed as

AdolescentAdultAgedCase-Control StudiesChildChild of Impaired ParentsChild, PreschoolCohort StudiesFemaleHumansMaleMiddle AgedMood DisordersParentsRisk FactorsYoung AdultEndophenotypesFamilial aggregationOffspring of bipolar and depressed parentsProspective studyRisk factors

Identifiers

PMID28396906
OpenAlexW2606261881

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.