Evidence map›Paper›PMID 28396861›Full record

ArticleFrontiers in cardiovascular medicine2017

Non-invasive Investigations for the Diagnosis of Fontan-Associated Liver Disease in Pediatric and Adult Fontan Patients.

Amyna Fidai, Frederic Dallaire, Nanette Alvarez, Yvonne Balon, Robin Clegg, Michael Connelly, Frank Dicke, Deborah Fruitman, Joyce Harder, Kimberley Myers and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Amyna FidaiDepartment of Paediatrics, Cumming School of Medicine, Alberta Children's Hospital Research Institute, University of Calgary , Calgary, AB , Canada.
Frederic DallaireDivision of Pediatric Cardiology, University of Sherbrooke, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke , Sherbrooke, QC , Canada.
Nanette AlvarezLibin Cardiovascular Institute of Alberta, University of Calgary , Calgary, AB , Canada.
Yvonne BalonLibin Cardiovascular Institute of Alberta, University of Calgary , Calgary, AB , Canada.
Robin CleggDepartment of Paediatrics, Cumming School of Medicine, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada; Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, AB, Canada.
Michael ConnellyLibin Cardiovascular Institute of Alberta, University of Calgary , Calgary, AB , Canada.
Frank DickeDepartment of Paediatrics, Cumming School of Medicine, Alberta Children's Hospital Research Institute, University of Calgary , Calgary, AB , Canada.
Deborah FruitmanDepartment of Paediatrics, Cumming School of Medicine, Alberta Children's Hospital Research Institute, University of Calgary , Calgary, AB , Canada.
Joyce HarderDepartment of Paediatrics, Cumming School of Medicine, Alberta Children's Hospital Research Institute, University of Calgary , Calgary, AB , Canada.
Kimberley MyersDepartment of Paediatrics, Cumming School of Medicine, Alberta Children's Hospital Research Institute, University of Calgary , Calgary, AB , Canada.
David J PattonDepartment of Paediatrics, Cumming School of Medicine, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada; Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, AB, Canada.
Tim PrieurLibin Cardiovascular Institute of Alberta, University of Calgary , Calgary, AB , Canada.
Erika VorhiesDepartment of Paediatrics, Cumming School of Medicine, Alberta Children's Hospital Research Institute, University of Calgary , Calgary, AB , Canada.
Robert P MyersLiver Unit, Division of Gastroenterology, Cumming School of Medicine, University of Calgary , Calgary, AB , Canada.
Steven R MartinDepartment of Paediatrics, Cumming School of Medicine, Alberta Children's Hospital Research Institute, University of Calgary , Calgary, AB , Canada.
Steven C GreenwayDepartment of Paediatrics, Cumming School of Medicine, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada; Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, AB, Canada.
University of Calgary · CAUniversité de Sherbrooke · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fontan-associated liver disease (FALD) is a serious complication related to the chronically elevated venous pressure and low cardiac output of this abnormal circulation. However, diagnostic markers for this condition are limited. We hypothesized that specific tests for fibrosis developed for other chronic liver diseases would identify a higher prevalence of FALD than ultrasound and standard laboratory tests and that identified abnormalities would correlate with time post-Fontan. In this cross-sectional study, we assessed 19 children (average age 8.4 ± 4.3 and 5.4 ± 4.1 years post-Fontan) and 8 adults (average age 31.5 ± 8.9 and 21.1 ± 4 years post-Fontan) using standard serum laboratory investigations assessing hepatic integrity and function, the FibroTest, liver ultrasound, and transient elastography (FibroScan). In adult Fontan patients, hemoglobin, C-reactive protein, and gamma-glutamyl transpeptidase were significantly increased, and white blood cell and platelet counts were significantly decreased in comparison to the pediatric cohort. International normalized ratio was mildly elevated in both children and adults. FibroTest results were suggestive of fibrosis regardless of time post-Fontan. FibroScan measurements were significantly correlated with time post-Fontan, but the incidence of ultrasound-detected liver abnormalities was variable. No cases of hepatocellular carcinoma were identified. Abnormalities suggestive of FALD occur in both children and adults post-Fontan. Select laboratory tests, and possibly ultrasound and FibroScan in some patients, appear to have the most promise for the non-invasive detection of FALD.

Indexed as

congenital heart diseasefibrosisFontanFontan-associated liver diseaseliver

Identifiers

PMID28396861
PMCPMC5366328
OpenAlexW2609741507

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.