Evidence map›Paper›PMID 28396653›Full record

ArticleFrontiers in endocrinology2017

Reduced Hepatic Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Level in Obesity.

Garrett Heinrich, Harrison T Muturi, Khadijeh Rezaei, Qusai Y Al-Share, Anthony M DeAngelis, Thomas A Bowman, Hilda E Ghadieh, Simona S Ghanem, Deqiang Zhang, Robert S Garofalo and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Insulin Clearance in Obesity and Type 2 Diabetes.International journal of molecular sciences · 2022
    Review
  5. Article
  6. Review
  7. Transcriptome Analysis of Testis from HFD-Induced Obese Rats (International journal of molecular sciences · 2020
    Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Garrett HeinrichDepartment of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA; Diabetes Institute, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.
Harrison T MuturiDepartment of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University , Athens, OH , USA.
Khadijeh RezaeiCenter for Diabetes and Endocrine Research (CeDER), College of Medicine and Life Sciences, University of Toledo , Toledo, OH , USA.
Qusai Y Al-ShareCenter for Diabetes and Endocrine Research (CeDER), College of Medicine and Life Sciences, University of Toledo , Toledo, OH , USA.
Anthony M DeAngelisCenter for Diabetes and Endocrine Research (CeDER), College of Medicine and Life Sciences, University of Toledo , Toledo, OH , USA.
Thomas A BowmanCenter for Diabetes and Endocrine Research (CeDER), College of Medicine and Life Sciences, University of Toledo , Toledo, OH , USA.
Hilda E GhadiehCenter for Diabetes and Endocrine Research (CeDER), College of Medicine and Life Sciences, University of Toledo , Toledo, OH , USA.
Simona S GhanemCenter for Diabetes and Endocrine Research (CeDER), College of Medicine and Life Sciences, University of Toledo , Toledo, OH , USA.
Deqiang ZhangDepartment of Molecular and Integrative Physiology, University of Michigan Medical School , Ann Arbor, MI , USA.
Robert S GarofaloYale Cancer Center, Office of Research Affairs , New Haven, CT , USA.
Lei YinDepartment of Molecular and Integrative Physiology, University of Michigan Medical School , Ann Arbor, MI , USA.
Sonia M NajjarDepartment of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA; Diabetes Institute, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA; Center for Diabetes and Endocrine Research (CeDER), College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.
University of Toledo · USOhio University · USUniversity of Michigan–Ann Arbor · USYale Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Impairment of insulin clearance is being increasingly recognized as a critical step in the development of insulin resistance and metabolic disease. The carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) promotes insulin clearance. Null deletion or liver-specific inactivation of Ceacam1 in mice causes a defect in insulin clearance, insulin resistance, steatohepatitis, and visceral obesity. Immunohistological analysis revealed reduction of hepatic CEACAM1 in obese subjects with fatty liver disease. Thus, we aimed to determine whether this occurs at the hepatocyte level in response to systemic extrahepatic factors and whether this holds across species. Northern and Western blot analyses demonstrate that

Indexed as

carcinoembryonic antigen-related cell adhesion molecule 1fatty liver diseasehyperinsulinemiainsulin clearanceinsulin resistanceobesity

Identifiers

PMID28396653
PMCPMC5366977
OpenAlexW2597733146

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.